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The proteases and pathogenicity of parasitic protozoa.
McKerrow JH, Sun E, Rosenthal PJ, Bouvier J. McKerrow JH, et al. Among authors: rosenthal pj. Annu Rev Microbiol. 1993;47:821-53. doi: 10.1146/annurev.mi.47.100193.004133. Annu Rev Microbiol. 1993. PMID: 8257117 Review.
Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum.
Rosenthal PJ, Nelson RG. Rosenthal PJ, et al. Mol Biochem Parasitol. 1992 Mar;51(1):143-52. doi: 10.1016/0166-6851(92)90209-3. Mol Biochem Parasitol. 1992. PMID: 1565129
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D. Rosenthal PJ, et al. J Clin Invest. 1991 Nov;88(5):1467-72. doi: 10.1172/JCI115456. J Clin Invest. 1991. PMID: 1939639 Free PMC article.
Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development.
Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. Rosenthal PJ, et al. Mol Biochem Parasitol. 1989 Jun 15;35(2):177-83. doi: 10.1016/0166-6851(89)90120-5. Mol Biochem Parasitol. 1989. PMID: 2671722
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. Rosenthal PJ, et al. J Clin Invest. 1988 Nov;82(5):1560-6. doi: 10.1172/JCI113766. J Clin Invest. 1988. PMID: 3053784 Free PMC article.
Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase.
Salas F, Fichmann J, Lee GK, Scott MD, Rosenthal PJ. Salas F, et al. Among authors: rosenthal pj. Infect Immun. 1995 Jun;63(6):2120-5. doi: 10.1128/IAI.63.6.2120-2125.1995. Infect Immun. 1995. PMID: 7768590 Free PMC article.
Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases.
Rosenthal PJ, Ring CS, Chen X, Cohen FE. Rosenthal PJ, et al. J Mol Biol. 1994 Aug 12;241(2):312-6. doi: 10.1006/jmbi.1994.1506. J Mol Biol. 1994. PMID: 8057374
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
Rosenthal PJ, Lee GK, Smith RE. Rosenthal PJ, et al. J Clin Invest. 1993 Mar;91(3):1052-6. doi: 10.1172/JCI116262. J Clin Invest. 1993. PMID: 8450035 Free PMC article.
Structure-based inhibitor design by using protein models for the development of antiparasitic agents.
Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. Ring CS, et al. Among authors: rosenthal pj. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3583-7. doi: 10.1073/pnas.90.8.3583. Proc Natl Acad Sci U S A. 1993. PMID: 8475107 Free PMC article.
A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue.
Rosenthal PJ. Rosenthal PJ. Biochim Biophys Acta. 1993 Apr 29;1173(1):91-3. doi: 10.1016/0167-4781(93)90250-h. Biochim Biophys Acta. 1993. PMID: 8485161
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