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The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated.

Ross FB, Smith MT. Ross FB, et al. Pain. 1997 Nov;73(2):151-157. doi: 10.1016/S0304-3959(97)00093-6. Pain. 1997. PMID: 9415500

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith MT, Cabot PJ, Ross FB, Robertson AD, Lewis RJ. Smith MT, et al. Among authors: ross fb. Pain. 2002 Mar;96(1-2):119-27. doi: 10.1016/s0304-3959(01)00436-5. Pain. 2002. PMID: 11932068

Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain.

Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Nielsen CK, et al. Among authors: ross fb. Pain. 2007 Dec 5;132(3):289-300. doi: 10.1016/j.pain.2007.03.022. Epub 2007 Apr 30. Pain. 2007. PMID: 17467904

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat.

Nielsen CK, Ross FB, Smith MT. Nielsen CK, et al. Among authors: ross fb. J Pharmacol Exp Ther. 2000 Oct;295(1):91-9. J Pharmacol Exp Ther. 2000. PMID: 10991965

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats.

Ross FB, Wallis SC, Smith MT. Ross FB, et al. Pain. 2000 Feb;84(2-3):421-8. doi: 10.1016/s0304-3959(99)00230-4. Pain. 2000. PMID: 10666549

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.

Wei M, Ong L, Smith MT, Ross FB, Schmid K, Hoey AJ, Burstow D, Brown L. Wei M, et al. Among authors: ross fb. Heart Lung Circ. 2003;12(1):44-50. doi: 10.1046/j.1444-2892.2003.00160.x. Heart Lung Circ. 2003. PMID: 16352106

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