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SVCT1 and SVCT2: key proteins for vitamin C uptake.
Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. Savini I, et al. Amino Acids. 2008 Apr;34(3):347-55. doi: 10.1007/s00726-007-0555-7. Epub 2007 Jun 1. Amino Acids. 2008. PMID: 17541511 Review.
Translational control of the ascorbic acid transporter SVCT2 in human platelets.
Savini I, Catani MV, Arnone R, Rossi A, Frega G, Del Principe D, Avigliano L. Savini I, et al. Free Radic Biol Med. 2007 Mar 1;42(5):608-16. doi: 10.1016/j.freeradbiomed.2006.11.028. Epub 2006 Dec 2. Free Radic Biol Med. 2007. PMID: 17291984
The redox balance is obviously linked to the presence of antioxidants; in particular, vitamin C appears to be a key modulator of platelet oxidative state, since these cells physiologically accumulate ascorbic acid and, moreover, platelet ascorbate plays a role durin …
The redox balance is obviously linked to the presence of antioxidants; in particular, vitamin C appears to be a key modulator of plat …
Redox regulation of vitamin C transporter SVCT2 in C2C12 myotubes.
Savini I, Rossi A, Catani MV, Ceci R, Avigliano L. Savini I, et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):385-90. doi: 10.1016/j.bbrc.2007.07.007. Epub 2007 Jul 16. Biochem Biophys Res Commun. 2007. PMID: 17643393
We have previously demonstrated that skeletal muscle cells possess efficient systems for vitamin C accumulation; in particular, the SVCT2 transporter for ascorbic acid uptake seems to play a crucial role. ...
We have previously demonstrated that skeletal muscle cells possess efficient systems for vitamin C accumulation; in particular, the SVCT2 tr …
Biological role of vitamin C in keratinocytes.
Catani MV, Savini I, Rossi A, Melino G, Avigliano L. Catani MV, et al. Nutr Rev. 2005 Mar;63(3):81-90. doi: 10.1111/j.1753-4887.2005.tb00125.x. Nutr Rev. 2005. PMID: 15825810 Review.
Vitamin C recycling is enhanced in the adaptive response to leptin-induced oxidative stress in keratinocytes.
Savini I, Catani MV, Rossi A, Duranti G, Ranalli M, Melino G, Sabatini S, Avigliano L. Savini I, et al. J Invest Dermatol. 2003 Oct;121(4):786-93. doi: 10.1046/j.1523-1747.2003.12538.x. J Invest Dermatol. 2003. PMID: 14632197
We also evaluated the systems involved in the maintenance of a positive ascorbate/dehydroascorbate ratio, i.e., transport and recycling. ...In particular, leptin-treated cells showed an increased ability to reduce dehydroascorbate, both in a NADH, lipoic acid- and i …
We also evaluated the systems involved in the maintenance of a positive ascorbate/dehydroascorbate ratio, i.e., transport and recycli …
Characterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis.
Savini I, Catani MV, Rossi A, Duranti G, Melino G, Avigliano L. Savini I, et al. J Invest Dermatol. 2002 Feb;118(2):372-9. doi: 10.1046/j.0022-202x.2001.01624.x. J Invest Dermatol. 2002. PMID: 11841559
Epidermal keratinocytes undergo differentiation in response to several stimuli to form the cornified envelope, a structure that contributes to the barrier function of skin. ...Ascorbic acid, besides acting as a radical scavenger, has been shown to promote mesenchyma …
Epidermal keratinocytes undergo differentiation in response to several stimuli to form the cornified envelope, a structure that contr …
Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations.
Lupi A, Tenni R, Rossi A, Cetta G, Forlino A. Lupi A, et al. Amino Acids. 2008 Nov;35(4):739-52. doi: 10.1007/s00726-008-0055-4. Epub 2008 Mar 14. Amino Acids. 2008. PMID: 18340504 Review.
Prolidase deficiency is a rare recessive disorder caused by mutations in the prolidase gene and characterized by severe skin lesions. ...The pathophysiology of PD is still poorly understood; we offer here a review of the molecular mechanisms so far hypothesized....
Prolidase deficiency is a rare recessive disorder caused by mutations in the prolidase gene and characterized by severe skin lesions. …
Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage.
Catani MV, Rossi A, Costanzo A, Sabatini S, Levrero M, Melino G, Avigliano L. Catani MV, et al. Biochem J. 2001 May 15;356(Pt 1):77-85. doi: 10.1042/0264-6021:3560077. Biochem J. 2001. PMID: 11336638 Free PMC article.
UV irradiation is a major insult to the skin. We have shown previously that exogenous vitamin C (ascorbate) accumulates in HaCaT keratinocytes, thus conferring the ability to prevent radical formation and cell death elicited by UV-B. ...Using a cDNA microarray hybri …
UV irradiation is a major insult to the skin. We have shown previously that exogenous vitamin C (ascorbate) accumulates in HaCaT kera …
Physico-chemical properties of molten dimer ascorbate oxidase.
Nicolai E, Di Venere A, Rosato N, Rossi A, Finazzi Agro' A, Mei G. Nicolai E, et al. FEBS J. 2006 Nov;273(22):5194-204. doi: 10.1111/j.1742-4658.2006.05515.x. Epub 2006 Oct 24. FEBS J. 2006. PMID: 17059465
The possible presence of dimeric unfolding intermediates might offer a clue to understanding the relationship between tertiary and quaternary structure formation in dimers. ...The dimeric species is present even at 3 x 10(8) Pa, providing evidence that mechanically or chem …
The possible presence of dimeric unfolding intermediates might offer a clue to understanding the relationship between tertiary and qu …
Aspirin enhances thermotolerance in human erythroleukemic cells: an effect associated with the modulation of the heat shock response.
Amici C, Rossi A, Santoro MG. Amici C, et al. Cancer Res. 1995 Oct 1;55(19):4452-7. Cancer Res. 1995. PMID: 7671259
In the present report we describe that in human erythroleukemic cells, aspirin (400 microM), when administered during or immediately after a hyperthermic treatment, causes an increase in the amount of HSP70 synthesized and prolongs HSP70 synthesis for a period of se …
In the present report we describe that in human erythroleukemic cells, aspirin (400 microM), when administered during or immediately after …
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