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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates.
Jamei M, Dickinson GL, Rostami-Hodjegan A. Jamei M, et al. Drug Metab Pharmacokinet. 2009;24(1):53-75. doi: 10.2133/dmpk.24.53. Drug Metab Pharmacokinet. 2009. PMID: 19252336 Free article. Review.
A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four-way crossover study to compare the concentration-time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers.
Rostami-Hodjegan A, Shiran MR, Ayesh R, Grattan TJ, Burnett I, Darby-Dowman A, Tucker GT. Rostami-Hodjegan A, et al. Drug Dev Ind Pharm. 2002 May;28(5):523-31. doi: 10.1081/ddc-120003448. Drug Dev Ind Pharm. 2002. PMID: 12098841
302 results