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278 results
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A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance.
Johnson TN, Boussery K, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A. Johnson TN, et al. Clin Pharmacokinet. 2010 Mar;49(3):189-206. doi: 10.2165/11318160-000000000-00000. Clin Pharmacokinet. 2010. PMID: 20170207
Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment.
Rostami-Hodjegan A, Nurminen S, Jackson PR, Tucker GT. Rostami-Hodjegan A, et al. Pharmacogenetics. 1996 Apr;6(2):121-49. doi: 10.1097/00008571-199604000-00001. Pharmacogenetics. 1996. PMID: 9156692
Determination of drug-metabolizing enzyme activity in vivo: pharmacokinetic and statistical issues.
Tucker GT, Rostami-Hodjegan A, Jackson PR. Tucker GT, et al. Xenobiotica. 1998 Dec;28(12):1255-73. doi: 10.1080/004982598238895. Xenobiotica. 1998. PMID: 9890160 Review. No abstract available.
Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes.
Rostami-Hodjegan A, Wolff K, Hay AW, Raistrick D, Calvert R, Tucker GT. Rostami-Hodjegan A, et al. Br J Clin Pharmacol. 1999 Jul;48(1):43-52. doi: 10.1046/j.1365-2125.1999.00974.x. Br J Clin Pharmacol. 1999. PMID: 10383559 Free PMC article. Clinical Trial.
The antitussive effect of dextromethorphan in relation to CYP2D6 activity.
Abdul Manap R, Wright CE, Gregory A, Rostami-Hodjegan A, Meller ST, Kelm GR, Lennard MS, Tucker GT, Morice AH. Abdul Manap R, et al. Br J Clin Pharmacol. 1999 Sep;48(3):382-7. doi: 10.1046/j.1365-2125.1999.00029.x. Br J Clin Pharmacol. 1999. PMID: 10510150 Free PMC article. Clinical Trial.
Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition.
Moghadamnia AA, Rostami-Hodjegan A, Abdul-Manap R, Wright CE, Morice AH, Tucker GT. Moghadamnia AA, et al. Br J Clin Pharmacol. 2003 Jul;56(1):57-67. doi: 10.1046/j.1365-2125.2003.01853.x. Br J Clin Pharmacol. 2003. PMID: 12848776 Free PMC article. Clinical Trial.
Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver.
Wilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW, Tucker GT. Wilson ZE, et al. Br J Clin Pharmacol. 2003 Oct;56(4):433-40. doi: 10.1046/j.1365-2125.2003.01881.x. Br J Clin Pharmacol. 2003. PMID: 12968989 Free PMC article.
The effects of dose staggering on metabolic drug-drug interactions.
Yang J, Kjellsson M, Rostami-Hodjegan A, Tucker GT. Yang J, et al. Eur J Pharm Sci. 2003 Oct;20(2):223-32. doi: 10.1016/s0928-0987(03)00200-8. Eur J Pharm Sci. 2003. PMID: 14550889
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients.
Rostami-Hodjegan A, Amin AM, Spencer EP, Lennard MS, Tucker GT, Flanagan RJ. Rostami-Hodjegan A, et al. J Clin Psychopharmacol. 2004 Feb;24(1):70-8. doi: 10.1097/01.jcp.0000106221.36344.4d. J Clin Psychopharmacol. 2004. PMID: 14709950
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors.
Proctor NJ, Tucker GT, Rostami-Hodjegan A. Proctor NJ, et al. Xenobiotica. 2004 Feb;34(2):151-78. doi: 10.1080/00498250310001646353. Xenobiotica. 2004. PMID: 14985145
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