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Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.
Crewe HK, Barter ZE, Yeo KR, Rostami-Hodjegan A. Crewe HK, et al. Biopharm Drug Dispos. 2011 Sep;32(6):303-18. doi: 10.1002/bdd.760. Epub 2011 Jul 4. Biopharm Drug Dispos. 2011. PMID: 21725985
Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment.
Rostami-Hodjegan A, Nurminen S, Jackson PR, Tucker GT. Rostami-Hodjegan A, et al. Pharmacogenetics. 1996 Apr;6(2):121-49. doi: 10.1097/00008571-199604000-00001. Pharmacogenetics. 1996. PMID: 9156692
Population-based modeling to demonstrate extrapancreatic effects of tolbutamide.
Rostami-Hodjegan A, Peacey SR, George E, Heller SR, Tucker GT. Rostami-Hodjegan A, et al. Am J Physiol. 1998 Apr;274(4):E758-71. doi: 10.1152/ajpendo.1998.274.4.E758. Am J Physiol. 1998. PMID: 9575839
Determination of drug-metabolizing enzyme activity in vivo: pharmacokinetic and statistical issues.
Tucker GT, Rostami-Hodjegan A, Jackson PR. Tucker GT, et al. Xenobiotica. 1998 Dec;28(12):1255-73. doi: 10.1080/004982598238895. Xenobiotica. 1998. PMID: 9890160 Review. No abstract available.
In-vivo indices of enzyme activity: the effect of renal impairment on the assessment of CYP2D6 activity.
Rostami-Hodjegan A, Kroemer HK, Tucker GT. Rostami-Hodjegan A, et al. Pharmacogenetics. 1999 Jun;9(3):277-86. doi: 10.1097/00008571-199906000-00002. Pharmacogenetics. 1999. PMID: 10471059
The 1'-hydroxylation of Rac-bufuralol by rat brain microsomes.
Coleman T, Spellman EF, Rostami-Hodjegan A, Lennard MS, Tucker GT. Coleman T, et al. Drug Metab Dispos. 2000 Sep;28(9):1094-9. Drug Metab Dispos. 2000. PMID: 10950855
Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver.
Wilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW, Tucker GT. Wilson ZE, et al. Br J Clin Pharmacol. 2003 Oct;56(4):433-40. doi: 10.1046/j.1365-2125.2003.01881.x. Br J Clin Pharmacol. 2003. PMID: 12968989 Free PMC article.
The effects of dose staggering on metabolic drug-drug interactions.
Yang J, Kjellsson M, Rostami-Hodjegan A, Tucker GT. Yang J, et al. Eur J Pharm Sci. 2003 Oct;20(2):223-32. doi: 10.1016/s0928-0987(03)00200-8. Eur J Pharm Sci. 2003. PMID: 14550889
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors.
Proctor NJ, Tucker GT, Rostami-Hodjegan A. Proctor NJ, et al. Xenobiotica. 2004 Feb;34(2):151-78. doi: 10.1080/00498250310001646353. Xenobiotica. 2004. PMID: 14985145
Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.
Heydari A, Yeo KR, Lennard MS, Ellis SW, Tucker GT, Rostami-Hodjegan A. Heydari A, et al. Drug Metab Dispos. 2004 Nov;32(11):1213-7. doi: 10.1124/dmd.104.001180. Epub 2004 Aug 24. Drug Metab Dispos. 2004. PMID: 15328252
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