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465 results
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Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
O'Connor KA, Roth BL. O'Connor KA, et al. Among authors: roth bl. Nat Rev Drug Discov. 2005 Dec;4(12):1005-14. doi: 10.1038/nrd1900. Nat Rev Drug Discov. 2005. PMID: 16341065 Review.
Progress towards better understanding and treatment of major psychiatric illnesses.
Abbas A, Roth B. Abbas A, et al. Drug Discov Today. 2005 Jul 15;10(14):960-2. doi: 10.1016/S1359-6446(05)03523-3. Drug Discov Today. 2005. PMID: 16023053 No abstract available.
The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?
Davies MA, Compton-Toth BA, Hufeisen SJ, Meltzer HY, Roth BL. Davies MA, et al. Among authors: roth bl. Psychopharmacology (Berl). 2005 Apr;178(4):451-60. doi: 10.1007/s00213-004-2017-1. Epub 2004 Oct 13. Psychopharmacology (Berl). 2005. PMID: 15765260
Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders.
Roth BL, Hanizavareh SM, Blum AE. Roth BL, et al. Psychopharmacology (Berl). 2004 Jun;174(1):17-24. doi: 10.1007/s00213-003-1683-8. Epub 2003 Dec 2. Psychopharmacology (Berl). 2004. PMID: 15205874 Review.
Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis.
Roth BL, Xia Z. Roth BL, et al. Crit Rev Neurobiol. 2004;16(4):229-36. doi: 10.1615/critrevneurobiol.v16.i4.10. Crit Rev Neurobiol. 2004. PMID: 15862107 Review.
Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery.
Roth BL, Lopez E, Beischel S, Westkaemper RB, Evans JM. Roth BL, et al. Pharmacol Ther. 2004 May;102(2):99-110. doi: 10.1016/j.pharmthera.2004.03.004. Pharmacol Ther. 2004. PMID: 15163592 Review.
Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled?
Roth BL. Roth BL. Dialogues Clin Neurosci. 2006;8(3):303-9. doi: 10.31887/DCNS.2006.8.3/broth. Dialogues Clin Neurosci. 2006. PMID: 17117612 Free PMC article. Review.
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Setola V, Roth BL. Setola V, et al. Among authors: roth bl. Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87. doi: 10.1517/17425255.1.3.377. Expert Opin Drug Metab Toxicol. 2005. PMID: 16863450 Review.
Screening the receptorome: an efficient approach for drug discovery and target validation.
Strachan RT, Ferrara G, Roth BL. Strachan RT, et al. Among authors: roth bl. Drug Discov Today. 2006 Aug;11(15-16):708-16. doi: 10.1016/j.drudis.2006.06.012. Drug Discov Today. 2006. PMID: 16846798 Review.
Screening the receptorome yields validated molecular targets for drug discovery.
Roth BL, Kroeze WK. Roth BL, et al. Curr Pharm Des. 2006;12(14):1785-95. doi: 10.2174/138161206776873680. Curr Pharm Des. 2006. PMID: 16712488 Review.
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