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Page 1
Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Wacker D, et al. Among authors: roth bl. Cell. 2017 Jan 26;168(3):377-389.e12. doi: 10.1016/j.cell.2016.12.033. Cell. 2017. PMID: 28129538 Free PMC article.
Functional selectivity and classical concepts of quantitative pharmacology.
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Urban JD, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. doi: 10.1124/jpet.106.104463. Epub 2006 Jun 27. J Pharmacol Exp Ther. 2007. PMID: 16803859 Review.
WAY-100635 is a potent dopamine D4 receptor agonist.
Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. Chemel BR, et al. Among authors: roth bl. Psychopharmacology (Berl). 2006 Oct;188(2):244-51. doi: 10.1007/s00213-006-0490-4. Epub 2006 Aug 17. Psychopharmacology (Berl). 2006. PMID: 16915381
Relating protein pharmacology by ligand chemistry.
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Keiser MJ, et al. Among authors: roth bl. Nat Biotechnol. 2007 Feb;25(2):197-206. doi: 10.1038/nbt1284. Nat Biotechnol. 2007. PMID: 17287757
Predicting new molecular targets for known drugs.
Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Keiser MJ, et al. Among authors: roth bl. Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1. Nature. 2009. PMID: 19881490 Free PMC article.
The presynaptic component of the serotonergic system is required for clozapine's efficacy.
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Among authors: roth bl. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.
Chemical informatics and target identification in a zebrafish phenotypic screen.
Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL Jr, Roth BL, Peterson RT, Shoichet BK. Laggner C, et al. Among authors: roth bl. Nat Chem Biol. 2011 Dec 18;8(2):144-6. doi: 10.1038/nchembio.732. Nat Chem Biol. 2011. PMID: 22179068 Free PMC article.
Structure of the human κ-opioid receptor in complex with JDTic.
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Wu H, et al. Among authors: roth bl. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. Nature. 2012. PMID: 22437504 Free PMC article.
532 results