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57 results
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The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.
Rother RP, Bell L, Hillmen P, Gladwin MT. Rother RP, et al. JAMA. 2005 Apr 6;293(13):1653-62. doi: 10.1001/jama.293.13.1653. JAMA. 2005. PMID: 15811985 Review.
Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria.
Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. Rother RP, et al. Nat Biotechnol. 2007 Nov;25(11):1256-64. doi: 10.1038/nbt1344. Nat Biotechnol. 2007. PMID: 17989688
In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5.
Evans MJ, Rollins SA, Wolff DW, Rother RP, Norin AJ, Therrien DM, Grijalva GA, Mueller JP, Nye SH, Squinto SP, et al. Evans MJ, et al. Among authors: rother rp. Mol Immunol. 1995 Nov;32(16):1183-95. doi: 10.1016/0161-5890(95)00099-2. Mol Immunol. 1995. PMID: 8559143
Expression of recombinant transmembrane CD59 in paroxysmal nocturnal hemoglobinuria B cells confers resistance to human complement.
Rother RP, Rollins SA, Mennone J, Chodera A, Fidel SA, Bessler M, Hillmen P, Squinto SP. Rother RP, et al. Blood. 1994 Oct 15;84(8):2604-11. Blood. 1994. PMID: 7522635
Improvement in the symptoms of smooth muscle dystonia during eculizumab therapy in paroxysmal nocturnal hemoglobinuria.
Hill A, Rother RP, Hillmen P. Hill A, et al. Among authors: rother rp. Haematologica. 2005 Dec;90(12 Suppl):ECR40. Haematologica. 2005. PMID: 16464755
Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization.
Hill A, Rother RP, Arnold L, Kelly R, Cullen MJ, Richards SJ, Hillmen P. Hill A, et al. Among authors: rother rp. Haematologica. 2010 Apr;95(4):567-73. doi: 10.3324/haematol.2009.007229. Epub 2010 Feb 9. Haematologica. 2010. PMID: 20145265 Free PMC article.
A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody.
Rother RP, Fodor WL, Springhorn JP, Birks CW, Setter E, Sandrin MS, Squinto SP, Rollins SA. Rother RP, et al. J Exp Med. 1995 Nov 1;182(5):1345-55. doi: 10.1084/jem.182.5.1345. J Exp Med. 1995. PMID: 7595205 Free PMC article.
Role of porcine P-selectin in complement-dependent adhesion of human leukocytes to porcine endothelial cells.
Rollins SA, Johnson KK, Li L, Birks C, Matis LA, Rother RP. Rollins SA, et al. Among authors: rother rp. Transplantation. 2000 Apr 27;69(8):1659-67. doi: 10.1097/00007890-200004270-00023. Transplantation. 2000. PMID: 10836378
Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria.
Hill A, Rother RP, Wang X, Morris SM Jr, Quinn-Senger K, Kelly R, Richards SJ, Bessler M, Bell L, Hillmen P, Gladwin MT. Hill A, et al. Among authors: rother rp. Br J Haematol. 2010 May;149(3):414-25. doi: 10.1111/j.1365-2141.2010.08096.x. Epub 2010 Mar 8. Br J Haematol. 2010. PMID: 20230403 Clinical Trial.
Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
Brodsky RA, Young NS, Antonioli E, Risitano AM, Schrezenmeier H, Schubert J, Gaya A, Coyle L, de Castro C, Fu CL, Maciejewski JP, Bessler M, Kroon HA, Rother RP, Hillmen P. Brodsky RA, et al. Among authors: rother rp. Blood. 2008 Feb 15;111(4):1840-7. doi: 10.1182/blood-2007-06-094136. Epub 2007 Nov 30. Blood. 2008. PMID: 18055865 Clinical Trial.
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