Abstract
A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.
MeSH terms
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Acetylcholinesterase / metabolism*
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Cholinesterase Inhibitors / chemical synthesis
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology*
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Molecular Structure
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Polymers / chemical synthesis
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Polymers / chemistry
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Polymers / pharmacology*
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Tacrine / chemical synthesis
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Tacrine / chemistry
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Tacrine / pharmacology*
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Temperature*
Substances
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Cholinesterase Inhibitors
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Polymers
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Tacrine
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Acetylcholinesterase