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MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.
Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G. Lopez JP, et al. Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497. Nat Commun. 2017. PMID: 28530238 Free PMC article. Clinical Trial.
Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.
Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, McInerney S, MacQueen GM, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Sassi RB, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Yu J, Uher R; CAN-BIND Investigator Team. Kennedy SH, et al. J Clin Psychiatry. 2019 Feb 5;80(2):18m12202. doi: 10.4088/JCP.18m12202. J Clin Psychiatry. 2019. PMID: 30840787 Clinical Trial.
Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.
Ju C, Fiori LM, Belzeaux R, Theroux JF, Chen GG, Aouabed Z, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Li Q, Foster JA, Kennedy SH, Turecki G. Ju C, et al. Transl Psychiatry. 2019 Oct 8;9(1):254. doi: 10.1038/s41398-019-0589-0. Transl Psychiatry. 2019. PMID: 31594917 Free PMC article.
The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols.
MacQueen GM, Hassel S, Arnott SR, Jean A, Bowie CR, Bray SL, Davis AD, Downar J, Foster JA, Frey BN, Goldstein BI, Hall GB, Harkness KL, Harris J, Lam RW, Lebel C, Milev R, Müller DJ, Parikh SV, Rizvi S, Rotzinger S, Sharma GB, Soares CN, Turecki G, Vila-Rodriguez F, Yu J, Zamyadi M, Strother SC, Kennedy SH; CAN-BIND Investigator Team. MacQueen GM, et al. J Psychiatry Neurosci. 2019 Jul 1;44(4):223-236. doi: 10.1503/jpn.180036. J Psychiatry Neurosci. 2019. PMID: 30840428 Free PMC article.
Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants.
Nogovitsyn N, Souza R, Muller M, Srajer A, Hassel S, Arnott SR, Davis AD, Hall GB, Harris JK, Zamyadi M, Metzak PD, Ismail Z, Bray SL, Lebel C, Addington JM, Milev R, Harkness KL, Frey BN, Lam RW, Strother SC, Goldstein BI, Rotzinger S, Kennedy SH, MacQueen GM. Nogovitsyn N, et al. Neuroimage. 2019 Aug 15;197:589-597. doi: 10.1016/j.neuroimage.2019.05.017. Epub 2019 May 7. Neuroimage. 2019. PMID: 31075395
Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort.
Lam RW, Milev R, Rotzinger S, Andreazza AC, Blier P, Brenner C, Daskalakis ZJ, Dharsee M, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Geraci J, Giacobbe P, Feilotter HE, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, Liotti M, MacQueen GM, McAndrews MP, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Salomons TV, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Kennedy SH; CAN-BIND Investigator Team. Lam RW, et al. BMC Psychiatry. 2016 Apr 16;16:105. doi: 10.1186/s12888-016-0785-x. BMC Psychiatry. 2016. PMID: 27084692 Free PMC article. Clinical Trial.
GPR56/ADGRG1 is associated with response to antidepressant treatment.
Belzeaux R, Gorgievski V, Fiori LM, Lopez JP, Grenier J, Lin R, Nagy C, Ibrahim EC, Gascon E, Courtet P, Richard-Devantoy S, Berlim M, Chachamovich E, Théroux JF, Dumas S, Giros B, Rotzinger S, Soares CN, Foster JA, Mechawar N, Tall GG, Tzavara ET, Kennedy SH, Turecki G. Belzeaux R, et al. Nat Commun. 2020 Apr 2;11(1):1635. doi: 10.1038/s41467-020-15423-5. Nat Commun. 2020. PMID: 32242018 Free PMC article.
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