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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.
Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V. Gothe HJ, et al. Among authors: roukos v. Mol Cell. 2019 Jul 25;75(2):267-283.e12. doi: 10.1016/j.molcel.2019.05.015. Epub 2019 Jun 12. Mol Cell. 2019. PMID: 31202576 Free article.
53BP1-DNA repair enters a new liquid phase.
Piccinno R, Minneker V, Roukos V. Piccinno R, et al. Among authors: roukos v. EMBO J. 2019 Aug 15;38(16):e102871. doi: 10.15252/embj.2019102871. Epub 2019 Jul 29. EMBO J. 2019. PMID: 31355472 Free PMC article.
Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.
Bouwman BAM, Agostini F, Garnerone S, Petrosino G, Gothe HJ, Sayols S, Moor AE, Itzkovitz S, Bienko M, Roukos V, Crosetto N. Bouwman BAM, et al. Among authors: roukos v. Nat Protoc. 2020 Dec;15(12):3894-3941. doi: 10.1038/s41596-020-0397-2. Epub 2020 Nov 2. Nat Protoc. 2020. PMID: 33139954
Cohesin puts a break on distal homology hunt.
Papantonis A, Roukos V. Papantonis A, et al. Among authors: roukos v. Nat Cell Biol. 2021 Nov;23(11):1112-1114. doi: 10.1038/s41556-021-00791-x. Nat Cell Biol. 2021. PMID: 34750579 No abstract available.
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types.
Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M, Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nürnberg P, Marenduzzo D, Rippe K, Papantonis A. Zirkel A, et al. Among authors: roukos v. Mol Cell. 2018 May 17;70(4):730-744.e6. doi: 10.1016/j.molcel.2018.03.030. Epub 2018 Apr 26. Mol Cell. 2018. PMID: 29706538 Free article.
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D, Papantonis A. Zhang S, et al. Among authors: roukos v. Sci Adv. 2021 Oct 22;7(43):eabg8205. doi: 10.1126/sciadv.abg8205. Epub 2021 Oct 22. Sci Adv. 2021. PMID: 34678064 Free PMC article.
The biogenesis of chromosome translocations.
Roukos V, Misteli T. Roukos V, et al. Nat Cell Biol. 2014 Apr;16(4):293-300. doi: 10.1038/ncb2941. Nat Cell Biol. 2014. PMID: 24691255 Free PMC article. Review.
34 results