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Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.
Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL. Doherty JR, et al. Among authors: roush wr. Cancer Res. 2014 Feb 1;74(3):908-20. doi: 10.1158/0008-5472.CAN-13-2034. Epub 2013 Nov 27. Cancer Res. 2014. PMID: 24285728 Free PMC article.
Therapeutic targeting of casein kinase 1δ in breast cancer.
Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Rosenberg LH, et al. Among authors: roush wr. Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. Sci Transl Med. 2015. PMID: 26676609 Free PMC article.
CK1δ: an exploitable vulnerability in breast cancer.
Rosenberg LH, Cleveland JL, Roush WR, Duckett DR. Rosenberg LH, et al. Among authors: roush wr. Ann Transl Med. 2016 Dec;4(23):474. doi: 10.21037/atm.2016.12.15. Ann Transl Med. 2016. PMID: 28090530 Free PMC article. No abstract available.
227 results