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Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.
Liu Z, Gunasekaran K, Wang W, Razinkov V, Sekirov L, Leng E, Sweet H, Foltz I, Howard M, Rousseau AM, Kozlosky C, Fanslow W, Yan W. Liu Z, et al. Among authors: rousseau am. J Biol Chem. 2014 Feb 7;289(6):3571-90. doi: 10.1074/jbc.M113.513366. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24311787 Free PMC article.
Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
Allen JG, Mujacic M, Frohn MJ, Pickrell AJ, Kodama P, Bagal D, San Miguel T, Sickmier EA, Osgood S, Swietlow A, Li V, Jordan JB, Kim KW, Rousseau AC, Kim YJ, Caille S, Achmatowicz M, Thiel O, Fotsch CH, Reddy P, McCarter JD. Allen JG, et al. ACS Chem Biol. 2016 Oct 21;11(10):2734-2743. doi: 10.1021/acschembio.6b00460. Epub 2016 Aug 11. ACS Chem Biol. 2016. PMID: 27434622
Implications of matrix adducts to protein analyte ions for surface-enhanced laser desorption/ionization and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis in clinical chemistry.
de Boer D, Rousseau AM, Peulen JG, Wodzig WK. de Boer D, et al. Among authors: rousseau am. Rapid Commun Mass Spectrom. 2009 Dec;23(24):4047-51. doi: 10.1002/rcm.4304. Rapid Commun Mass Spectrom. 2009. PMID: 19924782 No abstract available.
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