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Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM. Motta JP, et al. Among authors: rousset p. Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1. Gastroenterology. 2011. PMID: 21199654
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF. Galipeau HJ, et al. Among authors: rousset p. Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8. Am J Gastroenterol. 2014. PMID: 24710505 Free PMC article.
Active thrombin produced by the intestinal epithelium controls mucosal biofilms.
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N. Motta JP, et al. Among authors: rousset p. Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w. Nat Commun. 2019. PMID: 31324782 Free PMC article.
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Motta JP, Rolland C, Edir A, Florence AC, Sagnat D, Bonnart C, Rousset P, Guiraud L, Quaranta-Nicaise M, Mas E, Bonnet D, Verdu EF, McKay DM, Buscail E, Alric L, Vergnolle N, Deraison C. Motta JP, et al. Among authors: rousset p. Mucosal Immunol. 2021 May;14(3):667-678. doi: 10.1038/s41385-021-00375-w. Epub 2021 Mar 5. Mucosal Immunol. 2021. PMID: 33674762 Free PMC article.
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
Motta JP, Palese S, Giorgio C, Chapman K, Denadai-Souza A, Rousset P, Sagnat D, Guiraud L, Edir A, Seguy C, Alric L, Bonnet D, Bournet B, Buscail L, Gilletta C, Buret AG, Wallace JL, Hollenberg MD, Oswald E, Barocelli E, Le Grand S, Le Grand B, Deraison C, Vergnolle N. Motta JP, et al. Among authors: rousset p. J Crohns Colitis. 2021 May 4;15(5):787-799. doi: 10.1093/ecco-jcc/jjaa229. J Crohns Colitis. 2021. PMID: 33201214 Free PMC article.
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N. Le Faouder P, et al. Among authors: rousset p. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23831705
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. Fournel A, et al. Among authors: rousset p. Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12. Gut. 2017. PMID: 26565000 Free PMC article.
190 results