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36 results
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A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance.
Johnson TN, Boussery K, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A. Johnson TN, et al. Clin Pharmacokinet. 2010 Mar;49(3):189-206. doi: 10.2165/11318160-000000000-00000. Clin Pharmacokinet. 2010. PMID: 20170207
Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.
Howgate EM, Rowland Yeo K, Proctor NJ, Tucker GT, Rostami-Hodjegan A. Howgate EM, et al. Xenobiotica. 2006 Jun;36(6):473-97. doi: 10.1080/00498250600683197. Xenobiotica. 2006. PMID: 16769646
Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.
Shiran MR, Proctor NJ, Howgate EM, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A. Shiran MR, et al. Xenobiotica. 2006 Jul;36(7):567-80. doi: 10.1080/00498250600761662. Xenobiotica. 2006. PMID: 16864504
Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences.
Inoue S, Howgate EM, Rowland-Yeo K, Shimada T, Yamazaki H, Tucker GT, Rostami-Hodjegan A. Inoue S, et al. Xenobiotica. 2006 Jun;36(6):499-513. doi: 10.1080/00498250600683262. Xenobiotica. 2006. PMID: 16865818
Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.
Rowland Yeo K, Jamei M, Yang J, Tucker GT, Rostami-Hodjegan A. Rowland Yeo K, et al. Eur J Pharm Sci. 2010 Mar 18;39(5):298-309. doi: 10.1016/j.ejps.2009.12.002. Epub 2009 Dec 16. Eur J Pharm Sci. 2010. PMID: 20025966
Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.
Guest EJ, Rowland-Yeo K, Rostami-Hodjegan A, Tucker GT, Houston JB, Galetin A. Guest EJ, et al. Br J Clin Pharmacol. 2011 Jan;71(1):72-87. doi: 10.1111/j.1365-2125.2010.03799.x. Br J Clin Pharmacol. 2011. PMID: 21143503 Free PMC article.
Prediction of time-dependent CYP3A4 drug-drug interactions by physiologically based pharmacokinetic modelling: impact of inactivation parameters and enzyme turnover.
Rowland Yeo K, Walsky RL, Jamei M, Rostami-Hodjegan A, Tucker GT. Rowland Yeo K, et al. Eur J Pharm Sci. 2011 Jun 14;43(3):160-73. doi: 10.1016/j.ejps.2011.04.008. Epub 2011 Apr 20. Eur J Pharm Sci. 2011. PMID: 21540107
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Ghobadi C, Johnson TN, Aarabi M, Almond LM, Allabi AC, Rowland-Yeo K, Jamei M, Rostami-Hodjegan A. Ghobadi C, et al. Clin Pharmacokinet. 2011 Dec 1;50(12):809-22. doi: 10.2165/11594420-000000000-00000. Clin Pharmacokinet. 2011. PMID: 22087867
Modeling and predicting drug pharmacokinetics in patients with renal impairment.
Rowland Yeo K, Aarabi M, Jamei M, Rostami-Hodjegan A. Rowland Yeo K, et al. Expert Rev Clin Pharmacol. 2011 Mar;4(2):261-74. doi: 10.1586/ecp.10.143. Expert Rev Clin Pharmacol. 2011. PMID: 22115405 Review.
Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility.
Houston JB, Rowland-Yeo K, Zanelli U. Houston JB, et al. Toxicol In Vitro. 2012 Dec;26(8):1265-71. doi: 10.1016/j.tiv.2011.12.016. Epub 2012 Jan 8. Toxicol In Vitro. 2012. PMID: 22244922
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