Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial.
Anderson CS, Summers D, Ouyang M, Sui Y, Johnson B, Billot L, Malavera A, Faigle R, Muñoz-Venturelli P, Day D, Liu X, Li Q, Song L, Robinson TG, González F, Urrutia-Goldsack F, Iacobelli M, Montalbano M, Pruski A, Delcourt C, Durham AC, Ebraimo A, Van Ta HH, Ghosh P, Leonhardt-Caprio A, Nguyen HT, Ton MD, Jan S, Liu H, Lindley RI, Arauz A, Mercado A, Zaidi WAW, Khatri P, Wang X, Urrutia VC; OPTIMISTmain Investigators.
Anderson CS, et al.
Lancet. 2025 May 31;405(10493):1909-1922. doi: 10.1016/S0140-6736(25)00549-5. Epub 2025 May 21.
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PMID: 40412428
Clinical Trial.