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High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.
Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M. Fernandez-Prada C, et al. Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):165-173. doi: 10.1016/j.ijpddr.2018.03.004. Epub 2018 Mar 16. Int J Parasitol Drugs Drug Resist. 2018. PMID: 29602064 Free PMC article.
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.
Fernandez-Prada C, Vincent IM, Brotherton MC, Roberts M, Roy G, Rivas L, Leprohon P, Smith TK, Ouellette M. Fernandez-Prada C, et al. PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005171. doi: 10.1371/journal.pntd.0005171. eCollection 2016 Dec. PLoS Negl Trop Dis. 2016. PMID: 27911896 Free PMC article.
Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate.
El Fadili K, Imbeault M, Messier N, Roy G, Gourbal B, Bergeron M, Tremblay MJ, Légaré D, Ouellette M. El Fadili K, et al. Antimicrob Agents Chemother. 2008 Feb;52(2):526-33. doi: 10.1128/AAC.01183-07. Epub 2007 Dec 10. Antimicrob Agents Chemother. 2008. PMID: 18070969 Free PMC article.
Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.
El Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, Saravia NG, Papadopoulou B, Légaré D, Ouellette M. El Fadili K, et al. Antimicrob Agents Chemother. 2005 May;49(5):1988-93. doi: 10.1128/AAC.49.5.1988-1993.2005. Antimicrob Agents Chemother. 2005. PMID: 15855523 Free PMC article.
Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan.
Plourde M, Coelho A, Keynan Y, Larios OE, Ndao M, Ruest A, Roy G, Rubinstein E, Ouellette M. Plourde M, et al. PLoS Negl Trop Dis. 2012 Jan;6(1):e1463. doi: 10.1371/journal.pntd.0001463. Epub 2012 Jan 17. PLoS Negl Trop Dis. 2012. PMID: 22272366 Free PMC article.
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