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Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.
Ruan X, Pereda A, Stassi DL, Zeidner D, Summers RG, Jackson M, Shivakumar A, Kakavas S, Staver MJ, Donadio S, Katz L. Ruan X, et al. J Bacteriol. 1997 Oct;179(20):6416-25. doi: 10.1128/jb.179.20.6416-6425.1997. J Bacteriol. 1997. PMID: 9335291 Free PMC article.
Novel antibacterial class.
Dandliker PJ, Pratt SD, Nilius AM, Black-Schaefer C, Ruan X, Towne DL, Clark RF, Englund EE, Wagner R, Weitzberg M, Chovan LE, Hickman RK, Daly MM, Kakavas S, Zhong P, Cao Z, David CA, Xuei X, Lerner CG, Soni NB, Bui M, Shen LL, Cai Y, Merta PJ, Saiki AY, Beutel BA. Dandliker PJ, et al. Antimicrob Agents Chemother. 2003 Dec;47(12):3831-9. doi: 10.1128/aac.47.12.3831-3839.2003. Antimicrob Agents Chemother. 2003. PMID: 14638491 Free PMC article.
siRNA-mediated off-target gene silencing triggered by a 7 nt complementation.
Lin X, Ruan X, Anderson MG, McDowell JA, Kroeger PE, Fesik SW, Shen Y. Lin X, et al. Nucleic Acids Res. 2005 Aug 9;33(14):4527-35. doi: 10.1093/nar/gki762. Print 2005. Nucleic Acids Res. 2005. PMID: 16091630 Free PMC article.
Mechanistic analysis of VDR-mediated renin suppression.
Nakane M, Ma J, Ruan X, Kroeger PE, Wu-Wong R. Nakane M, et al. Nephron Physiol. 2007;107(2):p35-44. doi: 10.1159/000106792. Epub 2007 Aug 8. Nephron Physiol. 2007. PMID: 17687191
Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.
Lerner CG, Kakavas SJ, Wagner C, Chang RT, Merta PJ, Ruan X, Metzger RE, Beutel BA. Lerner CG, et al. Antimicrob Agents Chemother. 2005 Jul;49(7):2767-77. doi: 10.1128/AAC.49.7.2767-2777.2005. Antimicrob Agents Chemother. 2005. PMID: 15980348 Free PMC article.
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