Rubinsztein DC - Search Results

1

The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.

Lichtenberg M, Mansilla A, Zecchini VR, Fleming A, Rubinsztein DC. Lichtenberg M, et al. Among authors: rubinsztein dc. Cell Death Dis. 2011 Aug 25;2(8):e196. doi: 10.1038/cddis.2011.81. Cell Death Dis. 2011. PMID: 21866175 Free PMC article.

2

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.

Wyttenbach A, Carmichael J, Swartz J, Furlong RA, Narain Y, Rankin J, Rubinsztein DC. Wyttenbach A, et al. Among authors: rubinsztein dc. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2898-903. doi: 10.1073/pnas.97.6.2898. Proc Natl Acad Sci U S A. 2000. PMID: 10717003 Free PMC article.

3

Alpha-Synuclein is degraded by both autophagy and the proteasome.

Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. J Biol Chem. 2003 Jul 4;278(27):25009-13. doi: 10.1074/jbc.M300227200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12719433 Free article.

4

Lithium induces autophagy by inhibiting inositol monophosphatase.

Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035. J Cell Biol. 2005. PMID: 16186256 Free PMC article.

5

The roles of intracellular protein-degradation pathways in neurodegeneration.

Rubinsztein DC. Rubinsztein DC. Nature. 2006 Oct 19;443(7113):780-6. doi: 10.1038/nature05291. Nature. 2006. PMID: 17051204 Review.

6

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.

Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC. Williams A, et al. Among authors: rubinsztein dc. Curr Top Dev Biol. 2006;76:89-101. doi: 10.1016/S0070-2153(06)76003-3. Curr Top Dev Biol. 2006. PMID: 17118264 Review.

7

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. J Biol Chem. 2007 Feb 23;282(8):5641-52. doi: 10.1074/jbc.M609532200. Epub 2006 Dec 20. J Biol Chem. 2007. PMID: 17182613 Free article.

8

Autophagy induction rescues toxicity mediated by proteasome inhibition.

Rubinsztein DC. Rubinsztein DC. Neuron. 2007 Jun 21;54(6):854-6. doi: 10.1016/j.neuron.2007.06.005. Neuron. 2007. PMID: 17582326 Free article.

9

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias.

Davies JE, Sarkar S, Rubinsztein DC. Davies JE, et al. Among authors: rubinsztein dc. BMC Biochem. 2007 Nov 22;8 Suppl 1(Suppl 1):S2. doi: 10.1186/1471-2091-8-S1-S2. BMC Biochem. 2007. PMID: 18047739 Free PMC article. Review.

10

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: rubinsztein dc. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.

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