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Chromosomal structure is altered by mutations that suppress or enhance position effect variegation.
Hayashi S, Ruddell A, Sinclair D, Grigliatti T. Hayashi S, et al. Among authors: ruddell a. Chromosoma. 1990 Oct;99(6):391-400. doi: 10.1007/BF01726690. Chromosoma. 1990. PMID: 2125551
Addition of any of the Su(var) mutations restores a more euchromatic morphology to this region. In situ hybridization to polytene chromosomes and DNA blot analyses of gene copy number demonstrate that the DNA of the w+ gene is less accessible to its probe in the variegatin …
Addition of any of the Su(var) mutations restores a more euchromatic morphology to this region. In situ hybridization to polytene chr …
A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster.
Sinclair DA, Ruddell AA, Brock JK, Clegg NJ, Lloyd VK, Grigliatti TA. Sinclair DA, et al. Among authors: ruddell aa. Genetics. 1992 Feb;130(2):333-44. Genetics. 1992. PMID: 1541393 Free PMC article.
Characterization of a group of dominant second chromosome suppressor of position-effect variegation (PEV) (Su(var)) mutants has revealed a variety of interesting properties, including: maternal-effect suppression of PEV, homozygous lethality or semilethality and mal …
Characterization of a group of dominant second chromosome suppressor of position-effect variegation (PEV) (Su(var)) mutants has revea …
Preferential expression of actin genes during oogenesis of Drosophila.
Ruddell A, Jacobs-Lorena M. Ruddell A, et al. Dev Biol. 1984 Sep;105(1):115-20. doi: 10.1016/0012-1606(84)90266-5. Dev Biol. 1984. PMID: 6205919
Accumulation of actin proteins was quantitated by a two-stage electrophoresis procedure. Egg chambers accumulate actins preferentially, resulting in a twofold enrichment over other nonyolk proteins. RNA gel blot hybridization experiments demonstrated a concom …
Accumulation of actin proteins was quantitated by a two-stage electrophoresis procedure. Egg chambers accumulate actins preferentiall …
Biphasic pattern of histone gene expression during Drosophila oogenesis.
Ruddell A, Jacobs-Lorena M. Ruddell A, et al. Proc Natl Acad Sci U S A. 1985 May;82(10):3316-9. doi: 10.1073/pnas.82.10.3316. Proc Natl Acad Sci U S A. 1985. PMID: 3923476 Free PMC article.
A large proportion of the histone mRNAs is associated with polysomes at all times, indicating that expression of histone genes is not strictly coupled to DNA synthesis. The burst of histone mRNA accumulation near the end of oogenesis may provide a store of maternal
A large proportion of the histone mRNAs is associated with polysomes at all times, indicating that expression of histone genes is not
Abrupt decline in the rate of accumulation of total protein and yolk in postvitellogenic egg chambers ofDrosophila.
Ruddell A, Jacobs-Lorena M. Ruddell A, et al. Wilehm Roux Arch Dev Biol. 1983 May;192(3-4):189-195. doi: 10.1007/BF00848689. Wilehm Roux Arch Dev Biol. 1983. PMID: 28305126
Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius.
Neiman PE, Ruddell A, Jasoni C, Loring G, Thomas SJ, Brandvold KA, Lee Rm, Burnside J, Delrow J. Neiman PE, et al. Among authors: ruddell a. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6378-83. doi: 10.1073/pnas.111144898. Epub 2001 May 15. Proc Natl Acad Sci U S A. 2001. PMID: 11353853 Free PMC article.
The transcriptional effects of deregulated myc gene overexpression are implicated in tumorigenesis in a spectrum of experimental and naturally occurring neoplasms. ...However, expression profiles of late metastatic tumors showed a large variation in concert with myc …
The transcriptional effects of deregulated myc gene overexpression are implicated in tumorigenesis in a spectrum of experimental and …
B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma.
Ruddell A, Harrell MI, Furuya M, Kirschbaum SB, Iritani BM. Ruddell A, et al. Neoplasia. 2011 Aug;13(8):748-57. doi: 10.1593/neo.11756. Neoplasia. 2011. PMID: 21847366 Free PMC article.
Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation.
Mezquita P, Parghi SS, Brandvold KA, Ruddell A. Mezquita P, et al. Among authors: ruddell a. Oncogene. 2005 Jan 27;24(5):889-901. doi: 10.1038/sj.onc.1208251. Oncogene. 2005. PMID: 15580293
Real-time RT-PCR analyses showed that Myc did not alter the VEGF mRNA content of these cell lines, indicating that a post-transcriptional mechanism regulates VEGF production. ...Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway, which doe …
Real-time RT-PCR analyses showed that Myc did not alter the VEGF mRNA content of these cell lines, indicating that a post-transcripti …
B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis.
Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM. Ruddell A, et al. Am J Pathol. 2003 Dec;163(6):2233-45. doi: 10.1016/S0002-9440(10)63581-X. Am J Pathol. 2003. PMID: 14633598 Free PMC article.
We examined the role of c-Myc in stimulating angiogenesis and lymphangiogenesis in a highly metastatic murine model of Burkitt's lymphoma (E micro -c-myc), where c-Myc is expressed exclusively in B lymphocytes. ...Lymphatic sinuses also increased in size and number within …
We examined the role of c-Myc in stimulating angiogenesis and lymphangiogenesis in a highly metastatic murine model of Burkitt's lymp …
Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis.
Parghi SS, Brandvold KA, Bowers SJ, Neiman PE, Ruddell A. Parghi SS, et al. Among authors: ruddell a. Oncogene. 2004 May 27;23(25):4413-21. doi: 10.1038/sj.onc.1207577. Oncogene. 2004. PMID: 15064748
This reduced Myc overexpression fails to block B-cell differentiation in resistant birds, while high Myc consistently blocks development at a late embryo stage in susceptible birds. This failure of Myc to block differentiation results in a normal pattern of posthatc …
This reduced Myc overexpression fails to block B-cell differentiation in resistant birds, while high Myc consistently blocks development at …
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