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Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Matthews DR, et al. Among authors: rudenski as. Diabetologia. 1985 Jul;28(7):412-9. doi: 10.1007/BF00280883. Diabetologia. 1985. PMID: 3899825
Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment.
Rudenski AS, Hadden DR, Atkinson AB, Kennedy L, Matthews DR, Merrett JD, Pockaj B, Turner RC. Rudenski AS, et al. Diabet Med. 1988 Jan;5(1):36-41. doi: 10.1111/j.1464-5491.1988.tb00938.x. Diabet Med. 1988. PMID: 2964326
Continuous infusion of glucose with model assessment: measurement of insulin resistance and beta-cell function in man.
Hosker JP, Matthews DR, Rudenski AS, Burnett MA, Darling P, Bown EG, Turner RC. Hosker JP, et al. Among authors: rudenski as. Diabetologia. 1985 Jul;28(7):401-11. doi: 10.1007/BF00280882. Diabetologia. 1985. PMID: 3899824
With normal insulin resistance defined as 1, the median resistance in normal subjects was 1.35 by CIGMA and 1.39 by clamp, and in diabetic patients 4.0 by CIGMA and 3.96 by clamp. ...
With normal insulin resistance defined as 1, the median resistance in normal subjects was 1.35 by CIGMA and 1.39 by clamp, and in dia …
The glucose stimulus-response curve of the beta-cell in physically trained humans, assessed by hyperglycemic clamps.
O'Rahilly SO, Hosker JP, Rudenski AS, Matthews DR, Burnett MA, Turner RC. O'Rahilly SO, et al. Among authors: rudenski as. Metabolism. 1988 Oct;37(10):919-23. doi: 10.1016/0026-0495(88)90147-3. Metabolism. 1988. PMID: 3050363
Beta-cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes.
O'Rahilly SP, Nugent Z, Rudenski AS, Hosker JP, Burnett MA, Darling P, Turner RC. O'Rahilly SP, et al. Among authors: rudenski as. Lancet. 1986 Aug 16;2(8503):360-4. doi: 10.1016/s0140-6736(86)90052-8. Lancet. 1986. PMID: 2874367
Simple empirical assessment of beta-cell function by a constant infusion of glucose test in normal and type 2 (non-insulin-dependent) diabetic subjects.
Levy JC, Rudenski A, Burnett M, Knight R, Matthews DR, Turner RC. Levy JC, et al. Among authors: rudenski a. Diabetologia. 1991 Jul;34(7):488-99. doi: 10.1007/BF00403285. Diabetologia. 1991. PMID: 1916054
Predicted concentrations correlated with clamp concentrations, r = 0.94 and r = 0.98 respectively, p less than 0.001, validating the vectors as empirical glucose dose-response curves. ...The G-I vector slopes correlated with obesity in both groups (r = 0.54 p less than 0.0 …
Predicted concentrations correlated with clamp concentrations, r = 0.94 and r = 0.98 respectively, p less than 0.001, validating the vectors …
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