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Vascular-specific growth factors and blood vessel formation.
Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Yancopoulos GD, et al. Among authors: rudge js. Nature. 2000 Sep 14;407(6801):242-8. doi: 10.1038/35025215. Nature. 2000. PMID: 11001067 Review.
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD. Rudge JS, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18363-70. doi: 10.1073/pnas.0708865104. Epub 2007 Nov 13. Proc Natl Acad Sci U S A. 2007. PMID: 18000042 Free PMC article.
Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.
Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson BR, Quaggin SE, Papadopoulos N, Wei Y, Rudge JS, Thurston G, Yancopoulos GD, Davis S. Daly C, et al. Among authors: rudge js. Sci Rep. 2018 Jan 11;8(1):505. doi: 10.1038/s41598-017-18912-8. Sci Rep. 2018. PMID: 29323190 Free PMC article.
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Daly C, et al. Among authors: rudge js. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15491-6. doi: 10.1073/pnas.0607538103. Epub 2006 Oct 9. Proc Natl Acad Sci U S A. 2006. PMID: 17030814 Free PMC article.
The anti-inflammatory actions of angiopoietin-1.
Thurston G, Rudge JS, Ioffe E, Papadopoulos N, Daly C, Vuthoori S, Daly T, Wiegand SJ, Yancopoulos GD. Thurston G, et al. Among authors: rudge js. EXS. 2005;(94):233-45. doi: 10.1007/3-7643-7311-3_16. EXS. 2005. PMID: 15617482 Review. No abstract available.
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, Kovac L, Xu A, Leidich R, Radziejewska E, Rafique A, Goldberg J, Jain V, Bailey K, Karow M, Fandl J, Samuelsson SJ, Ioffe E, Rudge JS, Daly TJ, Radziejewski C, Yancopoulos GD. Davis S, et al. Among authors: rudge js. Nat Struct Biol. 2003 Jan;10(1):38-44. doi: 10.1038/nsb880. Nat Struct Biol. 2003. PMID: 12469114
Cytokine traps: multi-component, high-affinity blockers of cytokine action.
Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, Pyles EA, Xu X, Daly TJ, Young MR, Fandl JP, Lee F, Carver S, McNay J, Bailey K, Ramakanth S, Hutabarat R, Huang TT, Radziejewski C, Yancopoulos GD, Stahl N. Economides AN, et al. Among authors: rudge js. Nat Med. 2003 Jan;9(1):47-52. doi: 10.1038/nm811. Epub 2002 Dec 16. Nat Med. 2003. PMID: 12483208
69 results