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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Ruefli AA, et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10833-8. doi: 10.1073/pnas.191208598. Epub 2001 Sep 4. Proc Natl Acad Sci U S A. 2001. PMID: 11535817 Free PMC article.
A role for P-glycoprotein in regulating cell death.
Johnstone RW, Ruefli AA, Tainton KM, Smyth MJ. Johnstone RW, et al. Among authors: ruefli aa. Leuk Lymphoma. 2000 Jun;38(1-2):1-11. doi: 10.3109/10428190009060314. Leuk Lymphoma. 2000. PMID: 10811443 Review.
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