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Catching a Gli-mpse of Hedgehog.
Ruiz i Altaba A. Ruiz i Altaba A. Cell. 1997 Jul 25;90(2):193-6. doi: 10.1016/s0092-8674(00)80325-6. Cell. 1997. PMID: 9244291 Review. No abstract available.
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
Sanchez P, Hernández AM, Stecca B, Kahler AJ, DeGueme AM, Barrett A, Beyna M, Datta MW, Datta S, Ruiz i Altaba A. Sanchez P, et al. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12561-6. doi: 10.1073/pnas.0404956101. Epub 2004 Aug 16. Proc Natl Acad Sci U S A. 2004. PMID: 15314219 Free PMC article.
Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach....
Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach....
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.
Sanchez P, Ruiz i Altaba A. Sanchez P, et al. Mech Dev. 2005 Feb;122(2):223-30. doi: 10.1016/j.mod.2004.10.002. Mech Dev. 2005. PMID: 15652709
Analyses of the cerebella of cyclopamine-treated animals show a severe reduction in tumor size and a large decrease in the number of Ptc1-expressing cells, as a readout of cells with an active Hu-Gli pathway, as well as an impairment of their proliferative ca …
Analyses of the cerebella of cyclopamine-treated animals show a severe reduction in tumor size and a large decrease in the num …
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A. Palma V, et al. Development. 2005 Jan;132(2):335-44. doi: 10.1242/dev.01567. Epub 2004 Dec 16. Development. 2005. PMID: 15604099 Free PMC article.
Consistently, we show that Shh regulates the self-renewal of neurosphere-forming stem cells and that it modulates proliferation of SVZ lineages by acting as a mitogen in cooperation with epidermal growth factor (EGF). Together, our data demonstrate a critical and co …
Consistently, we show that Shh regulates the self-renewal of neurosphere-forming stem cells and that it modulates proliferation of SVZ linea …
Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer.
Ruiz i Altaba A, Stecca B, Sánchez P. Ruiz i Altaba A, et al. Cancer Lett. 2004 Feb 20;204(2):145-57. doi: 10.1016/S0304-3835(03)00451-8. Cancer Lett. 2004. PMID: 15013214
Inappropriate pathway activation in a variety of precursor cells in model organisms leads to tumor formation while inhibition of the pathway in human tumor cells leads to a decrease in their proliferation. ...Such reagents would allow a rational therapeutic a …
Inappropriate pathway activation in a variety of precursor cells in model organisms leads to tumor formation while inhibition of the …
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.
Palma V, Ruiz i Altaba A. Palma V, et al. Development. 2004 Jan;131(2):337-45. doi: 10.1242/dev.00930. Epub 2003 Dec 17. Development. 2004. PMID: 14681189
The results show that SHH signaling endogenously regulates the number of embryonic and postnatal mouse neocortical cells with stem cell properties, and controls precursor proliferation in a concentration-dependent manner in cooperation with EGF signaling. These findings id …
The results show that SHH signaling endogenously regulates the number of embryonic and postnatal mouse neocortical cells with stem cell prop …
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code.
Ruiz i Altaba A, Nguyên V, Palma V. Ruiz i Altaba A, et al. Curr Opin Genet Dev. 2003 Oct;13(5):513-21. doi: 10.1016/j.gde.2003.08.005. Curr Opin Genet Dev. 2003. PMID: 14550418 Review.
The secreted ligand Shh has been shown to act as a mitogen, morphogen and survival factor in different contexts whereas the three Gli transcription factors act as Shh mediators in a context-dependent combinatorial fashion. ...
The secreted ligand Shh has been shown to act as a mitogen, morphogen and survival factor in different contexts whereas the three Gli …
Pathways and consequences: Hedgehog signaling in human disease.
Mullor JL, Sánchez P, Ruiz i Altaba A. Mullor JL, et al. Trends Cell Biol. 2002 Dec;12(12):562-9. doi: 10.1016/s0962-8924(02)02405-4. Trends Cell Biol. 2002. PMID: 12495844 Review.
Signaling pathways that play a fundamental role during development are turning out to underlie many disease states when misregulated. ...We present a summary of the diseases that result from the inactivation or inappropriate activation of the Hh pathway. The human p …
Signaling pathways that play a fundamental role during development are turning out to underlie many disease states when misregulated. …
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway.
Stecca B, Ruiz i Altaba A. Stecca B, et al. J Biol. 2002 Nov 6;1(2):9. doi: 10.1186/1475-4924-1-9. J Biol. 2002. PMID: 12437768 Free PMC article. Review.
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex p …
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in …
Gli and hedgehog in cancer: tumours, embryos and stem cells.
Ruiz i Altaba A, Sánchez P, Dahmane N. Ruiz i Altaba A, et al. Nat Rev Cancer. 2002 May;2(5):361-72. doi: 10.1038/nrc796. Nat Rev Cancer. 2002. PMID: 12044012 Review.
Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lead to the onset of a tumorigenic programme and that these factors are prime targets for anticancer therapies....
Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lea …
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