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1999 1
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84 results

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Page 1
The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts.
Samowitz P, Radnai L, Vaissiere T, Michaelson SD, Rojas C, Mitchell R, Kilinc M, Edwards A, Shumate J, Hawkins R, Fernandez-Vega V, Spicer TP, Scampavia L, Kamenecka T, Miller CA, Rumbaugh G. Samowitz P, et al. Among authors: rumbaugh g. Nat Commun. 2025 Dec 9;16(1):10970. doi: 10.1038/s41467-025-65971-x. Nat Commun. 2025. PMID: 41366089 Free PMC article.
Development of clinically viable non-muscle myosin II small molecule inhibitors.
Radnai L, Young EJ, Kikuti C, Toth K, Zhou M, Hafenbreidel M, Stremel RF, Lin L, Pasetto P, Jin X, Patel A, Conlon M, Briggs SB, Heidsieck L, Sweeney HL, Sellers J, Krieger-Burke T, Martin WH, Sisco J, Young S, Pearson P, Rumbaugh G, Araldi GL, Duddy SK, Cameron MD, Surman M, Houdusse A, Griffin PR, Kamenecka TM, Miller CA. Radnai L, et al. Among authors: rumbaugh g. Cell. 2025 Aug 21;188(17):4604-4621.e15. doi: 10.1016/j.cell.2025.06.006. Epub 2025 Jul 1. Cell. 2025. PMID: 40602401
Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders.
Ellegood J, Beauchamp A, Yee Y, Devenyi G, Ziolkowski J, Qiu L, Askalan R, Ayub M, Suetterlin P, Donovan A, Basson MA, Quesnel KM, Berube NG, Woo T, Beversdorf D, Bjornsson H, Blakely R, Crawley J, Crosbie J, Orr BO, Davis GW, Genestine M, DiCicco-Bloom E, Egan S, Fink KD, Asbury S, Lai J, Rilett K, Foster JA, Vincent JB, Frankland P, Georgiades S, Penagarikano O, Geschwind D, Giger RJ, Markx S, Gogos J, Golzio C, Pagani M, Gozzi A, Pacey LK, Hampson D, Huang TN, Yen TL, Hsueh YP, Iaboni A, Amar M, Iakoucheva LM, Jones JK, Kelly E, Kieffer B, Bae M, Jung H, Kim H, Park H, Roh JD, Kim E, Konopka G, Laliberte C, Lefebvre JL, Eagleson K, Levitt P, Bach AM, Cunningham TJ, Fisher E, Miller K, Mills A, Muotri A, Nicolson R, Noakes LS, Nieman BJ, Canales CP, Nord AS, Nutter LM, Tam E, Osborne LR, Clipperton-Allen A, Page D, Babineau B, Palmer TD, Yan K, Picketts D, Xia Q, Powell CM, Raznahan A, Robins DM, Rumbaugh G, Sengar AS, Salter MW, Schachar RJ, D'Abate L, Bradley CA, Scherer SW, Copping NW, Petkova SP, Silverman JL, Singh KK, Kim NS, Yoon KK, Ming GL, Song H, Spring S, Nakatani J, Nakai N, Nomura J, Takumi T, Taylor M, Tsai P, Bruce M, Jones KL, Van de Water J, Van Eede MC,… See abstract for full author list ➔ Ellegood J, et al. Among authors: rumbaugh g. bioRxiv [Preprint]. 2025 Mar 8:2025.03.04.641443. doi: 10.1101/2025.03.04.641443. bioRxiv. 2025. PMID: 40568076 Free PMC article. Preprint.
MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma.
Kenchappa RS, Radnai L, Young EJ, Zarco N, Lin L, Dovas A, Meyer CT, Haddock A, Hall A, Toth K, Canoll P, Nagaiah NKH, Rumbaugh G, Cameron MD, Kamenecka TM, Griffin PR, Miller CA, Rosenfeld SS. Kenchappa RS, et al. Among authors: rumbaugh g. Cell. 2025 Aug 21;188(17):4622-4639.e19. doi: 10.1016/j.cell.2025.05.019. Epub 2025 Jun 10. Cell. 2025. PMID: 40499543 Free article.
Mesoscale proximity labeling to study macro changes to chromatin occupancy.
Douglas CJ, Samowitz P, Tong F, Long A, Bradley CM, Radnai L, MacMillan DWC, Miller CA, Rumbaugh G, Seath CP. Douglas CJ, et al. Among authors: rumbaugh g. bioRxiv [Preprint]. 2025 Mar 15:2025.03.13.643041. doi: 10.1101/2025.03.13.643041. bioRxiv. 2025. PMID: 40161777 Free PMC article. Preprint.
The Endo-GeneScreen Platform Identifies Drug-Like Probes that Regulate Endogenous Protein Levels within Physiological Contexts.
Samowitz P, Radnai L, Vaissiere T, Michaelson SD, Rojas C, Mitchell R, Kilinc M, Edwards A, Shumate J, Hawkins R, Fernandez-Vega V, Spicer TP, Scampavia L, Kamenecka T, Miller CA, Rumbaugh G. Samowitz P, et al. Among authors: rumbaugh g. bioRxiv [Preprint]. 2025 Mar 13:2025.03.13.643156. doi: 10.1101/2025.03.13.643156. bioRxiv. 2025. Update in: Nat Commun. 2025 Dec 9;16(1):10970. doi: 10.1038/s41467-025-65971-x. PMID: 40161629 Free PMC article. Updated. Preprint.
Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential.
Radnai L, Young EJ, Kikuti C, Hafenbreidel M, Stremel RF, Lin L, Toth K, Pasetto P, Jin X, Patel A, Conlon M, Briggs S, Heidsieck L, Sweeney HL, Sellers J, Krieger-Burke T, Martin WH, Sisco J, Young S, Pearson P, Rumbaugh G, Araldi GL, Duddy SK, Cameron MD, Surman M, Houdusse A, Griffin PR, Kamenecka TM, Miller CA. Radnai L, et al. Among authors: rumbaugh g. bioRxiv [Preprint]. 2024 Oct 12:2024.10.07.617018. doi: 10.1101/2024.10.07.617018. bioRxiv. 2024. Update in: Cell. 2025 Aug 21;188(17):4604-4621.e15. doi: 10.1016/j.cell.2025.06.006. PMID: 39416074 Free PMC article. Updated. Preprint.
MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma.
Kenchappa R, Radnai L, Young EJ, Zarco N, Lin L, Dovas A, Meyer CT, Haddock A, Hall A, Canoll P, Cameron MD, Nagaiah NK, Rumbaugh G, Griffin PR, Kamenecka TM, Miller CA, Rosenfeld SS. Kenchappa R, et al. Among authors: rumbaugh g. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591399. doi: 10.1101/2024.04.27.591399. bioRxiv. 2024. Update in: Cell. 2025 Aug 21;188(17):4622-4639.e19. doi: 10.1016/j.cell.2025.05.019. PMID: 38746089 Free PMC article. Updated. Preprint.
84 results