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PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Yu K, Lucas J, Zhu T, Zask A, Gaydos C, Toral-Barza L, Gu J, Li F, Chaudhary I, Cai P, Lotvin J, Petersen R, Ruppen M, Fawzi M, Ayral-Kaloustian S, Skotnicki J, Mansour T, Frost P, Gibbons J. Yu K, et al. Cancer Biol Ther. 2005 May;4(5):538-45. doi: 10.4161/cbt.4.5.1660. Epub 2005 May 28. Cancer Biol Ther. 2005. PMID: 15846106
Polyene antibiotics from Streptomyces mediocidicus.
Cai P, Kong F, Fink P, Ruppen ME, Williamson RT, Keiko T. Cai P, et al. Among authors: ruppen me. J Nat Prod. 2007 Feb;70(2):215-9. doi: 10.1021/np060542f. J Nat Prod. 2007. PMID: 17315962
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