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Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity.
Lemeer S, Zörgiebel C, Ruprecht B, Kohl K, Kuster B. Lemeer S, et al. Among authors: ruprecht b. J Proteome Res. 2013 Apr 5;12(4):1723-31. doi: 10.1021/pr301073j. Epub 2013 Mar 28. J Proteome Res. 2013. PMID: 23495751
Our data confirmed Aurora A, B, and BCR-ABL as the main targets of tozasertib and identified TNK1, STK2, RPS6KA1, and RPS6KA3 as submicromolar off targets....
Our data confirmed Aurora A, B, and BCR-ABL as the main targets of tozasertib and identified TNK1, STK2, RPS6KA1, and RPS6KA3 as subm …
Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis.
Ruprecht B, Zaal EA, Zecha J, Wu W, Berkers CR, Kuster B, Lemeer S. Ruprecht B, et al. Cancer Res. 2017 Apr 15;77(8):1842-1853. doi: 10.1158/0008-5472.CAN-16-2976. Epub 2017 Feb 16. Cancer Res. 2017. PMID: 28209619
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Médard G, Schwalbe H, Kuster B. Heinzlmeir S, et al. Among authors: ruprecht b. ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. doi: 10.1021/acschembio.6b00709. Epub 2016 Nov 7. ACS Chem Biol. 2016. PMID: 27768280
A bead-based western for high-throughput cellular signal transduction analyses.
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, Joos TO, Kling S, Poetz O, Fehm T, Neubauer H, Kuster B, Templin MF. Treindl F, et al. Among authors: ruprecht b. Nat Commun. 2016 Sep 23;7:12852. doi: 10.1038/ncomms12852. Nat Commun. 2016. PMID: 27659302 Free PMC article.
Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells.
Koch H, Wilhelm M, Ruprecht B, Beck S, Frejno M, Klaeger S, Kuster B. Koch H, et al. Among authors: ruprecht b. J Proteome Res. 2016 Dec 2;15(12):4490-4504. doi: 10.1021/acs.jproteome.6b00621. Epub 2016 Nov 16. J Proteome Res. 2016. PMID: 27794612
The target landscape of clinical kinase drugs.
Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B. Klaeger S, et al. Among authors: ruprecht b. Science. 2017 Dec 1;358(6367):eaan4368. doi: 10.1126/science.aan4368. Science. 2017. PMID: 29191878 Free PMC article.
MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome.
Ruprecht B, Roesli C, Lemeer S, Kuster B. Ruprecht B, et al. Proteomics. 2016 May;16(10):1447-56. doi: 10.1002/pmic.201500523. Epub 2016 May 2. Proteomics. 2016. PMID: 26990019
Evaluation of Kinase Activity Profiling Using Chemical Proteomics.
Ruprecht B, Zecha J, Heinzlmeir S, Médard G, Lemeer S, Kuster B. Ruprecht B, et al. ACS Chem Biol. 2015 Dec 18;10(12):2743-52. doi: 10.1021/acschembio.5b00616. Epub 2015 Oct 5. ACS Chem Biol. 2015. PMID: 26378887
Optimized chemical proteomics assay for kinase inhibitor profiling.
Médard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T, Wu Z, Dittmann A, Hopf C, Kramer K, Kuster B. Médard G, et al. Among authors: ruprecht b. J Proteome Res. 2015 Mar 6;14(3):1574-86. doi: 10.1021/pr5012608. Epub 2015 Feb 20. J Proteome Res. 2015. PMID: 25660469
Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns.
Ruprecht B, Koch H, Medard G, Mundt M, Kuster B, Lemeer S. Ruprecht B, et al. Mol Cell Proteomics. 2015 Jan;14(1):205-15. doi: 10.1074/mcp.M114.043109. Epub 2014 Nov 13. Mol Cell Proteomics. 2015. PMID: 25394399 Free PMC article.
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