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The enzymes, regulation, and genetics of bile acid synthesis.
Russell DW. Russell DW. Annu Rev Biochem. 2003;72:137-74. doi: 10.1146/annurev.biochem.72.121801.161712. Epub 2003 Jan 16. Annu Rev Biochem. 2003. PMID: 12543708 Review.
Christian Raetz: scientist and friend extraordinaire.
Dowhan W, Nikaido H, Stubbe J, Kozarich JW, Wickner WT, Russell DW, Garrett TA, Brozek K, Modrich P. Dowhan W, et al. Among authors: russell dw. Annu Rev Biochem. 2013;82:1-24. doi: 10.1146/annurev-biochem-012512-091530. Epub 2013 Mar 7. Annu Rev Biochem. 2013. PMID: 23472605
CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions.
Stiles AR, McDonald JG, Bauman DR, Russell DW. Stiles AR, et al. Among authors: russell dw. J Biol Chem. 2009 Oct 16;284(42):28485-9. doi: 10.1074/jbc.R109.042168. Epub 2009 Aug 16. J Biol Chem. 2009. PMID: 19687010 Free PMC article. Review.
Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.
Russell DW, Halford RW, Ramirez DM, Shah R, Kotti T. Russell DW, et al. Annu Rev Biochem. 2009;78:1017-40. doi: 10.1146/annurev.biochem.78.072407.103859. Annu Rev Biochem. 2009. PMID: 19489738 Free PMC article. Review.
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
Halford RW, Russell DW. Halford RW, et al. Among authors: russell dw. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3502-6. doi: 10.1073/pnas.0813349106. Epub 2009 Feb 9. Proc Natl Acad Sci U S A. 2009. PMID: 19204288 Free PMC article.
Fifty years of advances in bile acid synthesis and metabolism.
Russell DW. Russell DW. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S120-5. doi: 10.1194/jlr.R800026-JLR200. Epub 2008 Sep 24. J Lipid Res. 2009. PMID: 18815433 Free PMC article. Review.
Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function.
Shea HC, Head DD, Setchell KD, Russell DW. Shea HC, et al. Among authors: russell dw. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11526-33. doi: 10.1073/pnas.0705089104. Epub 2007 Jun 29. Proc Natl Acad Sci U S A. 2007. PMID: 17601774 Free PMC article.
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW. Chen W, et al. Among authors: russell dw. Cell Metab. 2007 Jan;5(1):73-9. doi: 10.1016/j.cmet.2006.11.012. Cell Metab. 2007. PMID: 17189208 Free PMC article.
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW. Cheng JB, et al. Among authors: russell dw. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5. doi: 10.1073/pnas.0402490101. Epub 2004 May 5. Proc Natl Acad Sci U S A. 2004. PMID: 15128933 Free PMC article.
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, Russell DW. Lund EG, et al. Among authors: russell dw. J Biol Chem. 2003 Jun 20;278(25):22980-8. doi: 10.1074/jbc.M303415200. Epub 2003 Apr 9. J Biol Chem. 2003. PMID: 12686551
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