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Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells.
Ghaly H, Jörns A, Rustenbeck I. Ghaly H, et al. Eur J Pharm Sci. 2014 Feb 14;52:206-14. doi: 10.1016/j.ejps.2013.11.011. Epub 2013 Nov 24. Eur J Pharm Sci. 2014. PMID: 24284031
Effects of fluoroquinolones on HERG channels and on pancreatic beta-cell ATP-sensitive K+ channels.
Zünkler BJ, Claassen S, Wos-Maganga M, Rustenbeck I, Holzgrabe U. Zünkler BJ, et al. Toxicology. 2006 Dec 7;228(2-3):239-48. doi: 10.1016/j.tox.2006.09.002. Epub 2006 Sep 8. Toxicology. 2006. PMID: 17027138
An inhibition of the cardiac rapid delayed rectifier K(+) current (I(Kr)) and of the ATP-sensitive K(+) (K(ATP)) current seems to be involved in the mechanisms of the cardiotoxic effects and the alterations in glucose homeostasis, respectively, induced by some fluoroquinol …
An inhibition of the cardiac rapid delayed rectifier K(+) current (I(Kr)) and of the ATP-sensitive K(+) (K(ATP)) current seems to be …
Palmitate-induced Ca2+-signaling in pancreatic beta-cells.
Remizov O, Jakubov R, Düfer M, Krippeit Drews P, Drews G, Waring M, Brabant G, Wienbergen A, Rustenbeck I, Schöfl C. Remizov O, et al. Mol Cell Endocrinol. 2003 Dec 30;212(1-2):1-9. doi: 10.1016/j.mce.2003.09.026. Mol Cell Endocrinol. 2003. PMID: 14654245
As a rise in cytosolic free Ca2+ ([Ca(2+)]i) is a key event for the stimulation of insulin secretion, the effects of saturated FFA on [Ca2+]i were investigated. Palmitate was used as a reference compound and [Ca2+]i was measured in single fura-2 loaded HIT-T1 …
As a rise in cytosolic free Ca2+ ([Ca(2+)]i) is a key event for the stimulation of insulin secretion, the effects of saturated FFA on …
Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues.
Rustenbeck I, Krautheim A, Jörns A, Steinfelder HJ. Rustenbeck I, et al. Biochem Pharmacol. 2004 May 1;67(9):1733-41. doi: 10.1016/j.bcp.2004.01.016. Biochem Pharmacol. 2004. PMID: 15081872
Glucose but not KCl diminishes submembrane granule turnover in mouse beta-cells.
Brüning D, Reckers K, Drain P, Rustenbeck I. Brüning D, et al. Among authors: rustenbeck i. J Mol Endocrinol. 2017 Oct;59(3):311-324. doi: 10.1530/JME-17-0063. Epub 2017 Aug 1. J Mol Endocrinol. 2017. PMID: 28765259
Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution.
Schulze T, Morsi M, Brüning D, Schumacher K, Rustenbeck I. Schulze T, et al. Endocrine. 2016 Mar;51(3):440-7. doi: 10.1007/s12020-015-0701-z. Epub 2015 Jul 31. Endocrine. 2016. PMID: 26227244
The present side-by-side comparison of insulin secretion, cytosolic Ca(2+) concentration ([Ca(2+)] i ) and oxygen consumption rate (OCR) points out where similarities and differences exist between MIN6 cells and normal mouse beta cells. ...In MIN6 pseudo-islets, glucose wa …
The present side-by-side comparison of insulin secretion, cytosolic Ca(2+) concentration ([Ca(2+)] i ) and oxygen consumption rate (O …
Observer-independent quantification of insulin granule exocytosis and pre-exocytotic mobility by TIRF microscopy.
Matz M, Schumacher K, Hatlapatka K, Lorenz D, Baumann K, Rustenbeck I. Matz M, et al. Microsc Microanal. 2014 Feb;20(1):206-18. doi: 10.1017/S1431927613013767. Epub 2013 Nov 13. Microsc Microanal. 2014. PMID: 24230985
Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation.
Panten U, Willenborg M, Schumacher K, Hamada A, Ghaly H, Rustenbeck I. Panten U, et al. Metabolism. 2013 Oct;62(10):1375-86. doi: 10.1016/j.metabol.2013.05.006. Epub 2013 Jun 18. Metabolism. 2013. PMID: 23790612
Determination of beta-cell function: insulin secretion of isolated islets.
Willenborg M, Schumacher K, Rustenbeck I. Willenborg M, et al. Methods Mol Biol. 2012;933:189-201. doi: 10.1007/978-1-62703-068-7_12. Methods Mol Biol. 2012. PMID: 22893408
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