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Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
Burgey CS, Stump CA, Nguyen DN, Deng JZ, Quigley AG, Norton BR, Bell IM, Mosser SD, Salvatore CA, Rutledge RZ, Kane SA, Koblan KS, Vacca JP, Graham SL, Williams TM. Burgey CS, et al. Among authors: rutledge rz. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5052-6. doi: 10.1016/j.bmcl.2006.07.044. Epub 2006 Aug 2. Bioorg Med Chem Lett. 2006. PMID: 16889959
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.
Williams TM, Stump CA, Nguyen DN, Quigley AG, Bell IM, Gallicchio SN, Zartman CB, Wan BL, Penna KD, Kunapuli P, Kane SA, Koblan KS, Mosser SD, Rutledge RZ, Salvatore C, Fay JF, Vacca JP, Graham SL. Williams TM, et al. Among authors: rutledge rz. Bioorg Med Chem Lett. 2006 May 15;16(10):2595-8. doi: 10.1016/j.bmcl.2006.02.051. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16527483
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.
Shaw AW, Paone DV, Nguyen DN, Stump CA, Burgey CS, Mosser SD, Salvatore CA, Rutledge RZ, Kane SA, Koblan KS, Graham SL, Vacca JP, Williams TM. Shaw AW, et al. Among authors: rutledge rz. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4795-8. doi: 10.1016/j.bmcl.2007.06.062. Epub 2007 Jun 26. Bioorg Med Chem Lett. 2007. PMID: 17616394
Identification of a novel RAMP-independent CGRP receptor antagonist.
Zartman CB, Bell IM, Gallicchio SN, Graham SL, Kane SA, Mallee JJ, Rutledge RZ, Salvatore CA, Vacca JP, Williams TM. Zartman CB, et al. Among authors: rutledge rz. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6705-8. doi: 10.1016/j.bmcl.2011.09.056. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21982500
Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.
Fraley ME, Rubino RS, Hoffman WF, Hambaugh SR, Arrington KL, Hungate RW, Bilodeau MT, Tebben AJ, Rutledge RZ, Kendall RL, McFall RC, Huckle WR, Coll KE, Thomas KA. Fraley ME, et al. Among authors: rutledge rz. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. doi: 10.1016/s0960-894x(02)00827-2. Bioorg Med Chem Lett. 2002. PMID: 12443771
16 results