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Ciliated air-liquid cultures as an aid to diagnostic testing of primary ciliary dyskinesia.
Hirst RA, Rutman A, Williams G, O'Callaghan C. Hirst RA, et al. Chest. 2010 Dec;138(6):1441-7. doi: 10.1378/chest.10-0175. Epub 2010 Jul 8. Chest. 2010. PMID: 20616212
Cell culture helped to exclude PCD in eight patients for whom ciliary dyskinesia was present in > 70% of the initial brush biopsy sample, a level at which a rebiopsy would normally be requested. ...CONCLUSIONS: Ciliary dyskinesia was reduced following cell cultur …
Cell culture helped to exclude PCD in eight patients for whom ciliary dyskinesia was present in > 70% of the initial brush biopsy sample, …
The behaviour of both Listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture.
Fadaee-Shohada MJ, Hirst RA, Rutman A, Roberts IS, O'Callaghan C, Andrew PW. Fadaee-Shohada MJ, et al. PLoS One. 2010 May 4;5(5):e10450. doi: 10.1371/journal.pone.0010450. PLoS One. 2010. PMID: 20454610 Free PMC article.
These observations were dependent on the expression of genes required for invasion, intracellular survival and listerial cell to cell spread that are regulated by the transcriptional activator, positive regulatory factor A (PrfA)....
These observations were dependent on the expression of genes required for invasion, intracellular survival and listerial cell to cell spread …
Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis.
Hirst RA, Gosai B, Rutman A, Andrew PW, O'Callaghan C. Hirst RA, et al. Infect Immun. 2003 Oct;71(10):6095-100. doi: 10.1128/iai.71.10.6095-6100.2003. Infect Immun. 2003. PMID: 14500537 Free PMC article.
Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that has been neglected in the study of meningitis is the ependyma, which has been identified as a location of adult pluripotent cells. In …
Streptococcus pneumoniae meningitis remains a disease with a poor outcome for the patient. A region of the brain that h …
The effect of viscous loading on brain ependymal cilia.
O'Callaghan CL, Sikand K, Rutman A, Hirst RA. O'Callaghan CL, et al. Neurosci Lett. 2008 Jul 4;439(1):56-60. doi: 10.1016/j.neulet.2008.04.095. Epub 2008 May 2. Neurosci Lett. 2008. PMID: 18511193
Increased viscous loading was followed by a rapid decrease in CBF compared to baseline readings (p<0.001). After 15min of exposure to the increased viscous load, CBF reached a new stable level while the viscous load was maintained. Compared to baseline measuremen …
Increased viscous loading was followed by a rapid decrease in CBF compared to baseline readings (p<0.001). After 15min of exposure …
Hydrogen peroxide at a concentration used during neurosurgery disrupts ciliary function and causes extensive damage to the ciliated ependyma of the brain.
Hirst RA, Rutman A, O'Callaghan C. Hirst RA, et al. Childs Nerv Syst. 2009 May;25(5):559-61. doi: 10.1007/s00381-008-0768-4. Epub 2008 Dec 24. Childs Nerv Syst. 2009. PMID: 19107492
OBJECTIVES: Hydrogen peroxide [H(2)O(2): 3% w/v (1.1 M)] has been used as a haemostatic agent during neurosurgery applied to both the external and ventricular surface of the brain. We hypothesised that H(2)O(2) would be toxic to the ciliated ependyma, a single layer …
OBJECTIVES: Hydrogen peroxide [H(2)O(2): 3% w/v (1.1 M)] has been used as a haemostatic agent during neurosurgery applied to both the …
Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia.
O'Callaghan C, Rutman A, Williams G, Kulkarni N, Hayes J, Hirst RA. O'Callaghan C, et al. Among authors: rutman a. Respir Res. 2018 Jun 25;19(1):125. doi: 10.1186/s12931-018-0782-3. Respir Res. 2018. PMID: 29940967 Free PMC article.
Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.
Hirst RA, Jackson CL, Coles JL, Williams G, Rutman A, Goggin PM, Adam EC, Page A, Evans HJ, Lackie PM, O'Callaghan C, Lucas JS. Hirst RA, et al. PLoS One. 2014 Feb 25;9(2):e89675. doi: 10.1371/journal.pone.0089675. eCollection 2014. PLoS One. 2014. PMID: 24586956 Free PMC article.
RESULTS: Ciliary function was abnormal before and after culture in all subjects with PCD; 21 PCD subjects had a combination of static and uncoordinated twitching cilia, which became completely static following culture, a further 9 demonstrated a decreased cil …
RESULTS: Ciliary function was abnormal before and after culture in all subjects with PCD; 21 PCD subjects had a combination of static …
Ciliary dyskinesia is an early feature of respiratory syncytial virus infection.
Smith CM, Kulkarni H, Radhakrishnan P, Rutman A, Bankart MJ, Williams G, Hirst RA, Easton AJ, Andrew PW, O'Callaghan C. Smith CM, et al. Eur Respir J. 2014 Feb;43(2):485-96. doi: 10.1183/09031936.00205312. Epub 2013 Mar 21. Eur Respir J. 2014. PMID: 23520320
Respiratory syncytial virus is a major cause of respiratory disease. There are conflicting accounts of the response of human epithelial cells to respiratory syncytial virus and a lack of data on its effect on ciliary function. ...Interestingly, ciliated cultures sec …
Respiratory syncytial virus is a major cause of respiratory disease. There are conflicting accounts of the response of human epitheli …
Persistent disruption of ciliated epithelium following paediatric lung transplantation.
Thomas B, Aurora P, Spencer H, Elliott M, Rutman A, Hirst RA, O'Callaghan C. Thomas B, et al. Eur Respir J. 2012 Nov;40(5):1245-52. doi: 10.1183/09031936.00174711. Epub 2012 Apr 20. Eur Respir J. 2012. PMID: 22523358
Ciliary dysfunction is a feature of native airway epithelium in paediatric CF lung transplant recipients. The epithelium below the airway anastomosis shows profound ultrastructural abnormalities in both CF and NSLD lung transplant recipients, many months after transplantat …
Ciliary dysfunction is a feature of native airway epithelium in paediatric CF lung transplant recipients. The epithelium below the ai …
Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma.
Thomas B, Rutman A, Hirst RA, Haldar P, Wardlaw AJ, Bankart J, Brightling CE, O'Callaghan C. Thomas B, et al. J Allergy Clin Immunol. 2010 Oct;126(4):722-729.e2. doi: 10.1016/j.jaci.2010.05.046. Epub 2010 Jul 31. J Allergy Clin Immunol. 2010. PMID: 20673980
The ultrastructure of the epithelium was abnormal in severe asthma with a reduction in ciliated cells, an increase in dead cells, and ciliary disorientation compared with all other groups (P < .05). ...Ciliary dysfunction is a feature of moderate to severe asthma …
The ultrastructure of the epithelium was abnormal in severe asthma with a reduction in ciliated cells, an increase in dead cells, and …
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