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Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.
McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA. McDonald A, et al. Among authors: rutter ga. Biochem Soc Trans. 2010 Feb;38(Pt 1):205-8. doi: 10.1042/BST0380205. Biochem Soc Trans. 2010. PMID: 20074060 Review.
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.
Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA. Sun G, et al. Among authors: rutter ga. Diabetologia. 2010 May;53(5):924-36. doi: 10.1007/s00125-010-1692-1. Epub 2010 Mar 11. Diabetologia. 2010. PMID: 20221584 Free PMC article.
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.
Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA. Leclerc I, et al. Among authors: rutter ga. Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. doi: 10.1152/ajpendo.00532.2003. Epub 2004 Feb 10. Am J Physiol Endocrinol Metab. 2004. PMID: 14871885 Free article.
We have recently shown that forced increases in AMPK activity inhibit insulin secretion from MIN6 cells (da Silva Xavier G, Leclerc I, Varadi A, Tsuboi T, Moule SK, and Rutter GA. Biochem J 371: 761-774, 2003). Here, we explore whether 1) glucose, metformin, or lept …
We have recently shown that forced increases in AMPK activity inhibit insulin secretion from MIN6 cells (da Silva Xavier G, Leclerc I, Varad …
378 results