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AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.
Ruzin A, Keeney D, Bradford PA. Ruzin A, et al. J Antimicrob Chemother. 2007 May;59(5):1001-4. doi: 10.1093/jac/dkm058. Epub 2007 Mar 15. J Antimicrob Chemother. 2007. PMID: 17363424
A single cross-over achieved insertional inactivation of the adeB gene with a suicide plasmid construct carrying an adeB fragment obtained by PCR. ...CONCLUSIONS: The results of this study suggest that decreased susceptibility to tigecycline in the A. calcoac
A single cross-over achieved insertional inactivation of the adeB gene with a suicide plasmid construct carrying an adeB fragm
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.
Keeney D, Ruzin A, McAleese F, Murphy E, Bradford PA. Keeney D, et al. J Antimicrob Chemother. 2008 Jan;61(1):46-53. doi: 10.1093/jac/dkm397. Epub 2007 Oct 29. J Antimicrob Chemother. 2008. PMID: 17967850
Sequence analysis revealed a single nucleotide insertion in the open reading frame of the marR gene in less-susceptible strains of E. coli. CONCLUSIONS: This study suggested that a loss of MarR functionality due to a frameshift mutation resulted in constituti …
Sequence analysis revealed a single nucleotide insertion in the open reading frame of the marR gene in less-susceptible strains of E. …
Functional, biophysical, and structural bases for antibacterial activity of tigecycline.
Olson MW, Ruzin A, Feyfant E, Rush TS 3rd, O'Connell J, Bradford PA. Olson MW, et al. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. doi: 10.1128/AAC.01499-05. Antimicrob Agents Chemother. 2006. PMID: 16723578 Free PMC article.
Tigecycline is a novel glycylcycline antibiotic that possesses broad-spectrum activity against many clinically relevant species of bacterial pathogens. ...A molecular model of tigecycline bound to the ribosome was generated with the aid of a 3.40-angstrom res …
Tigecycline is a novel glycylcycline antibiotic that possesses broad-spectrum activity against many clinically relevant species of ba …
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Ruzin A, Singh G, Severin A, Yang Y, Dushin RG, Sutherland AG, Minnick A, Greenstein M, May MK, Shlaes DM, Bradford PA. Ruzin A, et al. Antimicrob Agents Chemother. 2004 Mar;48(3):728-38. doi: 10.1128/aac.48.3.728-738.2004. Antimicrob Agents Chemother. 2004. PMID: 14982757 Free PMC article.
The naturally occurring mannopeptimycins (formerly AC98-1 through AC98-5) are a novel class of glycopeptide antibiotics that are active against a wide variety of gram-positive bacteria. ...By using a radioactive mannopeptimycin derivative bearing a pho …
The naturally occurring mannopeptimycins (formerly AC98-1 through AC98-5) are a novel class of glycopeptide antibiotics that are acti …
Further evidence that a cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction.
Ruzin A, Severin A, Ritacco F, Tabei K, Singh G, Bradford PA, Siegel MM, Projan SJ, Shlaes DM. Ruzin A, et al. J Bacteriol. 2002 Apr;184(8):2141-7. doi: 10.1128/jb.184.8.2141-2147.2002. J Bacteriol. 2002. PMID: 11914345 Free PMC article.
Previous studies suggested that a Gly-containing branch of cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc], which is often referred to as lipid II, might serve as a nucleophilic acceptor in sortase-catalyzed anchoring of surface proteins in Staphylococcus aureus …
Previous studies suggested that a Gly-containing branch of cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc], which is often referr …
Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.
Ruzin A, Severin A, Moghazeh SL, Etienne J, Bradford PA, Projan SJ, Shlaes DM. Ruzin A, et al. Biochim Biophys Acta. 2003 May 2;1621(2):117-21. doi: 10.1016/s0304-4165(03)00028-x. Biochim Biophys Acta. 2003. PMID: 12726988
A chemically generated mutant of Staphylococcus aureus RN4220, GC6668, was isolated that had a fourfold increase in resistance to vancomycin. ...In a selected set of revertants, Tn917 insertion was mapped to a unique chromosomal region upstream of mprF
A chemically generated mutant of Staphylococcus aureus RN4220, GC6668, was isolated that had a fourfold increase in resistance
RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex.
Ruzin A, Immermann FW, Bradford PA. Ruzin A, et al. Microb Drug Resist. 2010 Jun;16(2):87-9. doi: 10.1089/mdr.2009.0131. Microb Drug Resist. 2010. PMID: 20438348
The relationship between expression of adeABC and minimal inhibitory concentration (MIC) of tigecycline was investigated by RT-PCR and statistical analyses in a population of 106 clinical isolates (MIC range, 0.0313-16 microg/ml) of Acinetobacter calcoaceticus-Acinetobacte …
The relationship between expression of adeABC and minimal inhibitory concentration (MIC) of tigecycline was investigated by RT-PCR and stati …
In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infections.
Petersen PJ, Ruzin A, Tuckman M, Jones CH. Petersen PJ, et al. Diagn Microbiol Infect Dis. 2010 Apr;66(4):407-18. doi: 10.1016/j.diagmicrobio.2009.11.009. Diagn Microbiol Infect Dis. 2010. PMID: 20226331 Clinical Trial.
Resistance development profiling of piperacillin in combination with the novel {beta}-lactamase inhibitor BLI-489.
Ruzin A, Petersen PJ, Jones CH. Ruzin A, et al. J Antimicrob Chemother. 2010 Feb;65(2):252-7. doi: 10.1093/jac/dkp435. Epub 2009 Dec 11. J Antimicrob Chemother. 2010. PMID: 20008048
METHODS: BLI-489 was used at a constant concentration of 4 mg/L. Spontaneous mutation frequency was measured on piperacillin/BLI-489-containing agar plates. ...Two AmpC-producing Pseudomonas aeruginosa strains had a mutation frequency of 6.52 x 10(-6) and 1.0 x 10(- …
METHODS: BLI-489 was used at a constant concentration of 4 mg/L. Spontaneous mutation frequency was measured on piperacillin/BLI-489- …
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Jones CH, Ruzin A, Tuckman M, Visalli MA, Petersen PJ, Bradford PA. Jones CH, et al. Antimicrob Agents Chemother. 2009 Mar;53(3):977-86. doi: 10.1128/AAC.01155-08. Epub 2008 Dec 15. Antimicrob Agents Chemother. 2009. PMID: 19075050 Free PMC article.
Three novel beta-lactamases are described: the ESBLs TEM-155 (Q39K, R164S, E240K) and SHV-105 (I8F, R43S, G156D, G238S, E240K) and a non-ESBL, SHV-48 (V119I). ...Pyrosequencing is a real-time sequencing-by-synthesis approach that was applied to SNP detection for TEM …
Three novel beta-lactamases are described: the ESBLs TEM-155 (Q39K, R164S, E240K) and SHV-105 (I8F, R43S, G156D, G238S, E240K) and a
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