Rydzewski RM - Search Results

1

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

Rydzewski RM, Burrill L, Mendonca R, Palmer JT, Rice M, Tahilramani R, Bass KE, Leung L, Gjerstad E, Janc JW, Pan L. Rydzewski RM, et al. J Med Chem. 2006 May 18;49(10):2953-68. doi: 10.1021/jm058289o. J Med Chem. 2006. PMID: 16686537

2

Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors.

Rydzewski RM, Bryant C, Oballa R, Wesolowski G, Rodan SB, Bass KE, Wong DH. Rydzewski RM, et al. Bioorg Med Chem. 2002 Oct;10(10):3277-84. doi: 10.1016/s0968-0896(02)00173-6. Bioorg Med Chem. 2002. PMID: 12150873

3

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

Palmer JT, Bryant C, Wang DX, Davis DE, Setti EL, Rydzewski RM, Venkatraman S, Tian ZQ, Burrill LC, Mendonca RV, Springman E, McCarter J, Chung T, Cheung H, Janc JW, McGrath M, Somoza JR, Enriquez P, Yu ZW, Strickley RM, Liu L, Venuti MC, Percival MD, Falgueyret JP, Prasit P, Oballa R, Riendeau D, Young RN, Wesolowski G, Rodan SB, Johnson C, Kimmel DB, Rodan G. Palmer JT, et al. Among authors: rydzewski rm. J Med Chem. 2005 Dec 1;48(24):7520-34. doi: 10.1021/jm058198r. J Med Chem. 2005. PMID: 16302794

4

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

Palmer JT, Rydzewski RM, Mendonca RV, Sperandio D, Spencer JR, Hirschbein BL, Lohman J, Beltman J, Nguyen M, Liu L. Palmer JT, et al. Among authors: rydzewski rm. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3434-9. doi: 10.1016/j.bmcl.2006.04.013. Epub 2006 Apr 27. Bioorg Med Chem Lett. 2006. PMID: 16644215

5

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

Cathers BE, Barrett C, Palmer JT, Rydzewski RM. Cathers BE, et al. Among authors: rydzewski rm. Bioorg Chem. 2002 Aug;30(4):264-75. doi: 10.1016/s0045-2068(02)00009-3. Bioorg Chem. 2002. PMID: 12392705

6

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

Falgueyret JP, Oballa RM, Okamoto O, Wesolowski G, Aubin Y, Rydzewski RM, Prasit P, Riendeau D, Rodan SB, Percival MD. Falgueyret JP, et al. Among authors: rydzewski rm. J Med Chem. 2001 Jan 4;44(1):94-104. doi: 10.1021/jm0003440. J Med Chem. 2001. PMID: 11141092

7

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.

Maag H, Rydzewski RM, McRoberts MJ, Crawford-Ruth D, Verheyden JP, Prisbe EJ. Maag H, et al. Among authors: rydzewski rm. J Med Chem. 1992 Apr 17;35(8):1440-51. doi: 10.1021/jm00086a013. J Med Chem. 1992. PMID: 1573638

8

Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.

Dang Q, Brown BS, Liu Y, Rydzewski RM, Robinson ED, van Poelje PD, Reddy MR, Erion MD. Dang Q, et al. Among authors: rydzewski rm. J Med Chem. 2009 May 14;52(9):2880-98. doi: 10.1021/jm900078f. J Med Chem. 2009. PMID: 19348494

9

Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.

Madhavan GV, McGee DP, Rydzewski RM, Boehme R, Martin JC, Prisbe EJ. Madhavan GV, et al. Among authors: rydzewski rm. J Med Chem. 1988 Sep;31(9):1798-804. doi: 10.1021/jm00117a021. J Med Chem. 1988. PMID: 2842505

10

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration.

Dang Q, Liu Y, Rydzewski RM, Brown BS, Robinson E, van Poelje PD, Colby TJ, Erion MD. Dang Q, et al. Among authors: rydzewski rm. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3412-6. doi: 10.1016/j.bmcl.2007.03.089. Epub 2007 Apr 2. Bioorg Med Chem Lett. 2007. PMID: 17459701

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