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Is oncogene addiction angiogenesis-dependent?
Folkman J, Ryeom S. Folkman J, et al. Cold Spring Harb Symp Quant Biol. 2005;70:389-97. doi: 10.1101/sqb.2005.70.042. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869776
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, Ryeom S. Zaslavsky A, et al. Blood. 2013 Apr 18;121(16):3205-15. doi: 10.1182/blood-2012-04-421172. Epub 2013 Feb 27. Blood. 2013. PMID: 23446734 Free PMC article.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. Min J, et al. Nat Med. 2010 Mar;16(3):286-94. doi: 10.1038/nm.2100. Epub 2010 Feb 14. Nat Med. 2010. PMID: 20154697 Free PMC article.
Role of endogenous angiogenesis inhibitors in Down syndrome.
Ryeom S, Folkman J. Ryeom S, et al. J Craniofac Surg. 2009 Mar;20 Suppl 1:595-6. doi: 10.1097/scs.0b013e3181927f47. J Craniofac Surg. 2009. PMID: 19795527
Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.
Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Ryeom S, et al. Cancer Cell. 2008 May;13(5):420-31. doi: 10.1016/j.ccr.2008.02.018. Cancer Cell. 2008. PMID: 18455125
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Baek KH, et al. Nature. 2009 Jun 25;459(7250):1126-30. doi: 10.1038/nature08062. Epub 2009 May 20. Nature. 2009. PMID: 19458618 Free PMC article.
One such gene is Down's syndrome candidate region-1 (DSCR1, also known as RCAN1), which encodes a protein that suppresses vascular endothelial growth factor (VEGF)-mediated angiogenic signalling by the calcineurin pathway. Here we show that DSCR1 is increased in Down's
One such gene is Down's syndrome candidate region-1 (DSCR1, also known as RCAN1), which encodes a protein that suppresses vascular en …
Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.
Gollogly LK, Ryeom SW, Yoon SS. Gollogly LK, et al. J Surg Res. 2007 Sep;142(1):129-36. doi: 10.1016/j.jss.2006.10.011. Epub 2007 Jul 5. J Surg Res. 2007. PMID: 17610901 Free PMC article.
Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.
Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS. Detwiller KY, et al. Cancer Res. 2005 Jul 1;65(13):5881-9. doi: 10.1158/0008-5472.CAN-04-4078. Cancer Res. 2005. PMID: 15994966
S.c. injection of cells with VEGF-A siRNAs into athymic nude mice led to slower-growing tumors, decreased blood vessel density, and greater apoptosis when compared with controls. ...
S.c. injection of cells with VEGF-A siRNAs into athymic nude mice led to slower-growing tumors, decreased blood vessel density, and g
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