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Multiplex qPCR assay for ultra sensitive detection of JCV DNA with simultaneous identification of genotypes that discriminates non-virulent from virulent variants.
Ryschkewitsch CF, Jensen PN, Major EO. Ryschkewitsch CF, et al. J Clin Virol. 2013 Jul;57(3):243-8. doi: 10.1016/j.jcv.2013.03.009. Epub 2013 Apr 23. J Clin Virol. 2013. PMID: 23619054 Free PMC article.
JC virus in CD34+ and CD19+ cells in patients with multiple sclerosis treated with natalizumab.
Frohman EM, Monaco MC, Remington G, Ryschkewitsch C, Jensen PN, Johnson K, Perkins M, Liebner J, Greenberg B, Monson N, Frohman TC, Douek D, Major EO. Frohman EM, et al. JAMA Neurol. 2014 May;71(5):596-602. doi: 10.1001/jamaneurol.2014.63. JAMA Neurol. 2014. PMID: 24664166
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.
Cortese I, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco M, Ryschkewitsch C, Major EO, Ohayon J, Schindler MK, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A. Cortese I, et al. N Engl J Med. 2019 Apr 25;380(17):1597-1605. doi: 10.1056/NEJMoa1815039. Epub 2019 Apr 10. N Engl J Med. 2019. PMID: 30969503 Clinical Trial.
JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.
Van Loy T, Thys K, Ryschkewitsch C, Lagatie O, Monaco MC, Major EO, Tritsmans L, Stuyver LJ. Van Loy T, et al. J Virol. 2015 Jan 15;89(2):1340-7. doi: 10.1128/JVI.02565-14. Epub 2014 Nov 12. J Virol. 2015. PMID: 25392214 Free PMC article.
Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy.
Perkins MR, Ryschkewitsch C, Liebner JC, Monaco MC, Himelfarb D, Ireland S, Roque A, Edward HL, Jensen PN, Remington G, Abraham T, Abraham J, Greenberg B, Kaufman C, LaGanke C, Monson NL, Xu X, Frohman E, Major EO, Douek DC. Perkins MR, et al. PLoS Pathog. 2012;8(11):e1003014. doi: 10.1371/journal.ppat.1003014. Epub 2012 Nov 8. PLoS Pathog. 2012. PMID: 23144619 Free PMC article. Clinical Trial.
BK virus antibody titers and intensity of infections after renal transplantation.
Bohl DL, Brennan DC, Ryschkewitsch C, Gaudreault-Keener M, Major EO, Storch GA. Bohl DL, et al. J Clin Virol. 2008 Oct;43(2):184-9. doi: 10.1016/j.jcv.2008.06.009. Epub 2008 Aug 3. J Clin Virol. 2008. PMID: 18676176 Free PMC article. Clinical Trial.
BK virus encephalopathy and sclerosing vasculopathy in a patient with hypohidrotic ectodermal dysplasia and immunodeficiency.
Darbinyan A, Major EO, Morgello S, Holland S, Ryschkewitsch C, Monaco MC, Naidich TP, Bederson J, Malaczynska J, Ye F, Gordon R, Cunningham-Rundles C, Fowkes M, Tsankova NM. Darbinyan A, et al. Acta Neuropathol Commun. 2016 Jul 13;4(1):73. doi: 10.1186/s40478-016-0342-3. Acta Neuropathol Commun. 2016. PMID: 27411570 Free PMC article.
Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid.
Ryschkewitsch C, Jensen P, Hou J, Fahle G, Fischer S, Major EO. Ryschkewitsch C, et al. J Virol Methods. 2004 Nov;121(2):217-21. doi: 10.1016/j.jviromet.2004.06.021. J Virol Methods. 2004. PMID: 15381359
Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories.
Rollison DE, Utaipat U, Ryschkewitsch C, Hou J, Goldthwaite P, Daniel R, Helzlsouer KJ, Burger PC, Shah KV, Major EO. Rollison DE, et al. Int J Cancer. 2005 Feb 20;113(5):769-74. doi: 10.1002/ijc.20641. Int J Cancer. 2005. PMID: 15499616
Lymphocyte gene expression and JC virus noncoding control region sequences are linked with the risk of progressive multifocal leukoencephalopathy.
Marshall LJ, Ferenczy MW, Daley EL, Jensen PN, Ryschkewitsch CF, Major EO. Marshall LJ, et al. Among authors: ryschkewitsch cf. J Virol. 2014 May;88(9):5177-83. doi: 10.1128/JVI.03221-13. Epub 2014 Feb 19. J Virol. 2014. PMID: 24554653 Free PMC article.
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