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Page 1
Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA. Begemann P, et al. Chem Res Toxicol. 2011 Jul 18;24(7):1048-61. doi: 10.1021/tx200055c. Epub 2011 Jun 9. Chem Res Toxicol. 2011. PMID: 21548641 Free PMC article.
In rodents, isoprene-induced tumors show unique point mutations (AT transversions) in the K-ras protooncogene at codon 61. Therefore, we investigated adducts formed after the reaction of 2'-deoxyadenosine (dAdo ) with the two monoepoxides of isoprene, 2-ethenyl-2-methyloxi …
In rodents, isoprene-induced tumors show unique point mutations (AT transversions) in the K-ras protooncogene at codon 61. Therefore, …
Roles of substrate distortion and intramolecular hydrogen bonding in enzymatic catalysis by scytalone dehydratase.
Zheng YJ, Basarab GS, Jordan DB. Zheng YJ, et al. Biochemistry. 2002 Jan 22;41(3):820-6. doi: 10.1021/bi015848u. Biochemistry. 2002. PMID: 11790103
A survey of 12 active-site amino acid residues reveals 4 site-directed mutants (H110N, N131A, F53A, and F53L) have higher relative values of k(cat) and k(cat)/K(m) for DDBO over scytalone and for DDBO over vermelone than the wild-type enzyme, thus suggesting …
A survey of 12 active-site amino acid residues reveals 4 site-directed mutants (H110N, N131A, F53A, and F53L) have higher relative values of …
Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.
Marks GT, Harris TK, Massiah MA, Mildvan AS, Harrison DH. Marks GT, et al. Biochemistry. 2001 Jun 12;40(23):6805-18. doi: 10.1021/bi0028237. Biochemistry. 2001. PMID: 11389594
This enediolic intermediate is formed from the abstraction of the pro-S C3 proton of DHAP by Asp-71 of MGS or the pro-R C3 proton of DHAP by Glu-165 of TIM. ...A competitive inhibitor of TIM, phosphoglycolohydroxamic acid (PGH) is found to be a tight binding competi …
This enediolic intermediate is formed from the abstraction of the pro-S C3 proton of DHAP by Asp-71 of MGS or the pro-R C3 pro …
Determination of the membrane potential of cultured mammalian Schwann cells and its sensitivity to potassium using a thiocarbocyanine fluorescent dye.
Hargittai PT, Youmans SJ, Lieberman EM. Hargittai PT, et al. Glia. 1991;4(6):611-6. doi: 10.1002/glia.440040608. Glia. 1991. PMID: 1835962
The membrane potential of cultured rat sciatic nerve Schwann cells was determined with conventional microelectrode and voltage-sensitive fluorescent dye, Di-S-C3(5), optical techniques. The value for membrane potential obtained with microelectrodes was -42.1 +/- 4.7 …
The membrane potential of cultured rat sciatic nerve Schwann cells was determined with conventional microelectrode and voltage-sensitive flu …
Acidification and ion permeabilities of highly purified rat liver endosomes.
Fuchs R, Mâle P, Mellman I. Fuchs R, et al. J Biol Chem. 1989 Feb 5;264(4):2212-20. J Biol Chem. 1989. PMID: 2914902 Free article.
In addition, changes in membrane potential accompanying ATP-dependent acidification were directly measured using the voltage-sensitive fluorescent dye Di-S-C3(5). Our results indicate that ATP-dependent acidification of liver endosomes is electrogenic, with proton t …
In addition, changes in membrane potential accompanying ATP-dependent acidification were directly measured using the voltage-sensitive fluor …
Na+/H+ exchange is present in basolateral membranes from rabbit small intestine.
Barros F, Domínguez P, Velasco G, Lazo PS. Barros F, et al. Biochem Biophys Res Commun. 1986 Jan 29;134(2):827-34. doi: 10.1016/s0006-291x(86)80495-8. Biochem Biophys Res Commun. 1986. PMID: 3004465
Fluorescence quenching of the pH gradient sensitive dye acridine orange and that of the membrane potential sensitive dye Di-S-C3(5) have been studied in purified basolateral membrane vesicles obtained from rabbit small intestine. ...Based on the comparison of acridi …
Fluorescence quenching of the pH gradient sensitive dye acridine orange and that of the membrane potential sensitive dye Di-S-C3 …
Effect of bacterial endotoxin on the transmembrane electrical potential and plasma membrane fluidity of human monocytes.
Larsen NE, Enelow RI, Simons ER, Sullivan R. Larsen NE, et al. Biochim Biophys Acta. 1985 Apr 26;815(1):1-8. doi: 10.1016/0005-2736(85)90466-3. Biochim Biophys Acta. 1985. PMID: 3986196
Using the fluorescent lipophilic cationic probe 3,3'-dipropylthiodicarbocyanine (di-S-C3(5] to monitor the transmembrane electrical potential, we found that neither endotoxin nor lipid A induced depolarization of the monocyte's plasma membrane or impeded its ability …
Using the fluorescent lipophilic cationic probe 3,3'-dipropylthiodicarbocyanine (di-S-C3(5] to monitor the transmembrane elect …
Activation of murine macrophage cell lines. Possible involvement of protein kinases in stimulation of superoxide production.
Kiyotaki C, Bloom BR. Kiyotaki C, et al. J Immunol. 1984 Aug;133(2):923-31. J Immunol. 1984. PMID: 6330204
Because membrane potential changes are seen in other systems of activation, membrane potential changes in the macrophages stimulated by PMA were measured both by means of the fluorescence ionophore, dis-S-C3-(5), and by direct measurement by using a K+-electr …
Because membrane potential changes are seen in other systems of activation, membrane potential changes in the macrophages stimulated by PMA …
Conformational analysis of a hybrid DNA-RNA double helical oligonucleotide in aqueous solution: d(CG)r(CG)d(CG) studied by 1D- and 2D-1H NMR spectroscopy.
Haasnoot CA, Westerink HP, van der Marel GA, van Boom JH. Haasnoot CA, et al. J Biomol Struct Dyn. 1983 Oct;1(1):131-49. doi: 10.1080/07391102.1983.10507430. J Biomol Struct Dyn. 1983. PMID: 6086057 Review.
Conformational analysis of the sugar rings of d(CG)r(CG)d(CG) at 300 K shows that the central ribonucleotide part of the helix adopts an A-type double helical conformation. ...It is shown that this A-to-B conformational transition can only be accommodated by two specific s …
Conformational analysis of the sugar rings of d(CG)r(CG)d(CG) at 300 K shows that the central ribonucleotide part of the helix adopts …
Transmembrane potential of isolated rat alveolar type II cells.
Castranova V, Jones GS, Miles PR. Castranova V, et al. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jun;54(6):1511-7. doi: 10.1152/jappl.1983.54.6.1511. J Appl Physiol Respir Environ Exerc Physiol. 1983. PMID: 6307943
Type II cells were isolated from rat lungs by elastase digestion and purified by centrifugal elutriation. The fluorescent dye, Di-S-C3(5), was used as a probe to monitor transmembrane potential (Em) of cells suspended in N-2-hydroxyethylpiperazine-N'-2-ethanesulfoni …
Type II cells were isolated from rat lungs by elastase digestion and purified by centrifugal elutriation. The fluorescent dye, Di-S- …
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