Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA.
Begemann P, et al.
Chem Res Toxicol. 2011 Jul 18;24(7):1048-61. doi: 10.1021/tx200055c. Epub 2011 Jun 9.
Chem Res Toxicol. 2011.
PMID: 21548641
Free PMC article.
In rodents, isoprene-induced tumors show unique point mutations (AT transversions) in the K-ras protooncogene at codon 61. Therefore, we investigated adducts formed after the reaction of 2'-deoxyadenosine (dAdo ) with the two monoepoxides of isoprene, 2-ethenyl-2-methyloxi …
In rodents, isoprene-induced tumors show unique point mutations (AT transversions) in the K-ras protooncogene at codon 61. Therefore, …