Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA.
Begemann P, et al.
Chem Res Toxicol. 2011 Jul 18;24(7):1048-61. doi: 10.1021/tx200055c. Epub 2011 Jun 9.
Chem Res Toxicol. 2011.
PMID: 21548641
Free PMC article.
Major stable adducts were identified by HPLC, UV-spectroscopy, and LC-MS/MS and characterized by (1)H NMR and (1)H,(13)C HSQC and HMBC NMR experiments. Adducts of IP-1,2-O that were fully identified are R,S-C1-N(6)-dAdo, R-C2-N(6)-dAdo, and S-C2-N(6)-dAdo; adducts of IP-3, …
Major stable adducts were identified by HPLC, UV-spectroscopy, and LC-MS/MS and characterized by (1)H NMR and (1)H,(13)C HSQC and HMB …