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2,303 results
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Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.
Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P. Clausen RP, et al. Bioorg Med Chem. 2005 Feb 1;13(3):895-908. doi: 10.1016/j.bmc.2004.10.029. Bioorg Med Chem. 2005. PMID: 15653355
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Frølund B, Jørgensen AT, Tagmose L, Stensbøl TB, Vestergaard HT, Engblom C, Kristiansen U, Sanchez C, Krogsgaard-Larsen P, Liljefors T. Frølund B, et al. J Med Chem. 2002 Jun 6;45(12):2454-68. doi: 10.1021/jm020027o. J Med Chem. 2002. PMID: 12036354
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Topiol S, Bang-Andersen B, Sanchez C, Plenge P, Loland CJ, Juhl K, Larsen K, Bregnedal P, Bøgesø KP. Topiol S, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):470-478. doi: 10.1016/j.bmcl.2016.12.037. Epub 2016 Dec 21. Bioorg Med Chem Lett. 2017. PMID: 28041833
Escitalopram versus citalopram: the surprising role of the R-enantiomer.
Sánchez C, Bøgesø KP, Ebert B, Reines EH, Braestrup C. Sánchez C, et al. Psychopharmacology (Berl). 2004 Jul;174(2):163-76. doi: 10.1007/s00213-004-1865-z. Psychopharmacology (Berl). 2004. PMID: 15160261 Review.
Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT.
Topiol S, Bang-Andersen B, Sanchez C, Bøgesø KP. Topiol S, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5058-5064. doi: 10.1016/j.bmcl.2016.08.087. Epub 2016 Aug 28. Bioorg Med Chem Lett. 2016. PMID: 27624075
R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter.
Stórustovu Sí, Sánchez C, Pörzgen P, Brennum LT, Larsen AK, Pulis M, Ebert B. Stórustovu Sí, et al. Br J Pharmacol. 2004 May;142(1):172-80. doi: 10.1038/sj.bjp.0705738. Epub 2004 Mar 22. Br J Pharmacol. 2004. PMID: 15037515 Free PMC article.
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Ebert B, Anderson NJ, Cremers TI, Rasmussen S, Vogel V, Fahey JM, Sánchez C. Ebert B, et al. Pharmacol Biochem Behav. 2008 Jul;90(1):113-22. doi: 10.1016/j.pbb.2008.01.021. Epub 2008 Feb 5. Pharmacol Biochem Behav. 2008. PMID: 18304623
Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects.
Larsen AK, Brennum LT, Egebjerg J, Sánchez C, Halldin C, Andersen PH. Larsen AK, et al. Br J Pharmacol. 2004 Mar;141(6):1015-23. doi: 10.1038/sj.bjp.0705693. Epub 2004 Mar 1. Br J Pharmacol. 2004. PMID: 14993096 Free PMC article.
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