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First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro.
Lund T, Søe K, Abildgaard N, Garnero P, Pedersen PT, Ormstrup T, Delaissé JM, Plesner T. Lund T, et al. Among authors: soe k. Eur J Haematol. 2010 Oct;85(4):290-9. doi: 10.1111/j.1600-0609.2010.01485.x. Epub 2010 Jul 22. Eur J Haematol. 2010. PMID: 20528908 Free PMC article. Clinical Trial.
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