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Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.
Strøbaek D, Hougaard C, Johansen TH, Sørensen US, Nielsen EØ, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P. Strøbaek D, et al. Among authors: sorensen us. Mol Pharmacol. 2006 Nov;70(5):1771-82. doi: 10.1124/mol.106.027110. Epub 2006 Aug 22. Mol Pharmacol. 2006. PMID: 16926279
Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.
Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H. Jenkins DP, et al. Among authors: sorensen us. Mol Pharmacol. 2011 Jun;79(6):899-909. doi: 10.1124/mol.110.069807. Epub 2011 Mar 1. Mol Pharmacol. 2011. PMID: 21363929 Free PMC article.
Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses.
Haugaard MM, Hesselkilde EZ, Pehrson S, Carstensen H, Flethøj M, Præstegaard KF, Sørensen US, Diness JG, Grunnet M, Buhl R, Jespersen T. Haugaard MM, et al. Among authors: sorensen us. Heart Rhythm. 2015 Apr;12(4):825-35. doi: 10.1016/j.hrthm.2014.12.028. Epub 2014 Dec 24. Heart Rhythm. 2015. PMID: 25542425
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