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23 results

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S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.
Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D, Calabrese V, Cuzzocrea S. Di Paola R, et al. Int J Mol Sci. 2022 Apr 17;23(8):4429. doi: 10.3390/ijms23084429. Int J Mol Sci. 2022. PMID: 35457246 Free PMC article.
A valid approach to protect against the disease would be to replenish the endogenous antioxidants; thus, we investigated the protective mechanisms of the S-acetyl-glutathione (SAG), a glutathione (GSH) prodrug. Preliminary in vitro analyses were conduc …
A valid approach to protect against the disease would be to replenish the endogenous antioxidants; thus, we investigated the protective mech …
S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations.
Galzigna L, Rizzoli V, Schiappelli P, Moretto C, Bernareggi A. Galzigna L, et al. Enzyme Protein. 1994-1995;48(2):98-104. doi: 10.1159/000474975. Enzyme Protein. 1994. PMID: 7581748
S-acetyl- and S-phenylacetyl-glutathione derivatives were synthesized by using a new procedure. ...A potential role of S-acetyl- and S-phenylacetyl-glutathione in replenishing cells with exogenous glutathione is envisaged....
S-acetyl- and S-phenylacetyl-glutathione derivatives were synthesized by using a new procedure. ...A potential role of
S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism.
Locigno R, Pincemail J, Henno A, Treusch G, Castronovo V. Locigno R, et al. Int J Oncol. 2002 Jan;20(1):69-75. Int J Oncol. 2002. PMID: 11743644
Agents able to restore the programmed cell death responsiveness of cancer cells are foreseen as potential effective cancer therapies. In this study, we report that a glutathione-S-derivative, S-acetyl-glutathione (Sag), induces significant apoptosis in …
Agents able to restore the programmed cell death responsiveness of cancer cells are foreseen as potential effective cancer therapies. In thi …
Antioxidant Effect of a Dietary Supplement Containing Fermentative S-Acetyl-Glutathione and Silybin in Dogs with Liver Disease.
Martello E, Perondi F, Bisanzio D, Lippi I, Meineri G, Gabriele V. Martello E, et al. Vet Sci. 2023 Feb 8;10(2):131. doi: 10.3390/vetsci10020131. Vet Sci. 2023. PMID: 36851435 Free PMC article.
Liver is the primary site for the synthesis of glutathione (GSH), the major intracellular antioxidant. GSH erythrocyte concentration can decrease in case of liver damage. ...In this case-control study, we tested a new supplement containing S-acetyl-glutath
Liver is the primary site for the synthesis of glutathione (GSH), the major intracellular antioxidant. GSH erythrocyte concentration …
Safety Assessment of S-Acetyl Glutathione for Use in Foods and Dietary Supplements.
Camillerapp C, Mayfield DB, Papineni S, Leroux A, Jeanne JF. Camillerapp C, et al. Food Chem Toxicol. 2025 Jan 30:115279. doi: 10.1016/j.fct.2025.115279. Online ahead of print. Food Chem Toxicol. 2025. PMID: 39892735 Free article.
S-Acetyl Glutathione (SAG) is a glutathione precursor used as a food or dietary ingredient in a bioavailable form to restore or maintain circulating glutathione (GSH) levels. ...
S-Acetyl Glutathione (SAG) is a glutathione precursor used as a food or dietary ingredient in a bioavailable for
Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease.
Marianetti M, Pinna S, Venuti A, Liguri G. Marianetti M, et al. Alzheimers Dement (N Y). 2022 Mar 13;8(1):e12278. doi: 10.1002/trc2.12278. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35310529 Free PMC article.
We performed a randomized cross-over clinical trial to evaluate their potential benefits in mild AD. METHODS: Oleuropein and S-acetyl glutathione were administered as dietary supplement for 6 months to 18 patients diagnosed for probable mild AD according to I …
We performed a randomized cross-over clinical trial to evaluate their potential benefits in mild AD. METHODS: Oleuropein and S-ace
Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo.
Kumar A, Ponnan P, Raj HG, Parmar VS, Saso L. Kumar A, et al. Food Chem Toxicol. 2013 Feb;52:216-24. doi: 10.1016/j.fct.2012.11.018. Epub 2012 Nov 23. Food Chem Toxicol. 2013. PMID: 23182742
We have earlier conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed modifications of functional proteins such as cytochrome-P450-linked mixed function oxidases (Cyt-P450-linked MFOs), NADPH cytochrome c reductase, and glutathione S-transferase by a …
We have earlier conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed modifications of functional proteins such as cy …
Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine.
Crinelli R, Zara C, Smietana M, Retini M, Magnani M, Fraternale A. Crinelli R, et al. Nutrients. 2019 Jun 7;11(6):1291. doi: 10.3390/nu11061291. Nutrients. 2019. PMID: 31181621 Free PMC article. Review.
Glutathione (GSH) has poor pharmacokinetic properties; thus, several derivatives and biosynthetic precursors have been proposed as GSH-boosting drugs. I-152 is a conjugate of N-acetyl-cysteine (NAC) and S-acetyl-beta-mercaptoethylamine (SMEA) designed to rele
Glutathione (GSH) has poor pharmacokinetic properties; thus, several derivatives and biosynthetic precursors have been proposed as GS
Comprehensive Profiling of Amine-Containing Metabolite Isomers with Chiral Phosphorus Reagents.
Liu X, Wu Y, Guo L, Wang X, Shan C, Liu Y, An H, Kang X, Ding R, Cai Z, Dong J, Zhao Y, Gao X. Liu X, et al. Anal Chem. 2023 Nov 21;95(46):16830-16839. doi: 10.1021/acs.analchem.3c02325. Epub 2023 Nov 9. Anal Chem. 2023. PMID: 37943818
Notably, it is the first time to identify S-acetyl-glutathione as an endogenous metabolite in liver cells. The SIPAL strategy could provide spectacular insight into the chemical structures and biological functions of the fascinating amine-containing metabolit …
Notably, it is the first time to identify S-acetyl-glutathione as an endogenous metabolite in liver cells. The SIPAL st …
Isolation of glyoxalase II from bovine liver mitochondria.
Talesa V, Principato GB, Norton SJ, Contenti S, Mangiabene C, Rosi G. Talesa V, et al. Biochem Int. 1990;20(1):53-8. Biochem Int. 1990. PMID: 2328024
The kinetic constants obtained using S-D-lactoyl, S-acetyl-, S-acetoacetyl-, and S-succinyl-glutathione as substrates are similar to those reported for glyoxalase II from rat liver mitochondria. S-D-Lactoyl- and S-acetoacetyl-glutathione are the best s …
The kinetic constants obtained using S-D-lactoyl, S-acetyl-, S-acetoacetyl-, and S-succinyl-glutathione as substrates a …
23 results