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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 1
1971 2
1972 1
1976 1
1977 3
1979 2
1980 6
1981 15
1982 14
1983 9
1984 13
1985 8
1986 12
1987 7
1988 20
1989 12
1990 9
1991 19
1992 20
1993 34
1994 17
1995 35
1996 43
1997 43
1998 43
1999 49
2000 60
2001 38
2002 44
2003 57
2004 82
2005 116
2006 88
2007 83
2008 114
2009 165
2010 193
2011 234
2012 229
2013 272
2014 326
2015 349
2016 320
2017 247
2018 389
2019 397
2020 459
2021 495
2022 578
2023 593
2024 482
2025 2

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6,155 results

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Page 1
Association between circadian rhythms and neurodegenerative diseases.
Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. Leng Y, et al. Lancet Neurol. 2019 Mar;18(3):307-318. doi: 10.1016/S1474-4422(18)30461-7. Epub 2019 Feb 12. Lancet Neurol. 2019. PMID: 30784558 Free PMC article. Review.
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. …
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in peop …
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E. Blackman J, et al. Among authors: leng y. J Sleep Res. 2021 Aug;30(4):e13229. doi: 10.1111/jsr.13229. Epub 2020 Dec 2. J Sleep Res. 2021. PMID: 33289311 Free PMC article. Review.
Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer's Disease (AD) progression. Several sleep interventions have been tested in established AD dementia cases. ...
Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer's Disease (AD) progression. Several sleep interventions …
Daytime napping and Alzheimer's dementia: A potential bidirectional relationship.
Li P, Gao L, Yu L, Zheng X, Ulsa MC, Yang HW, Gaba A, Yaffe K, Bennett DA, Buchman AS, Hu K, Leng Y. Li P, et al. Among authors: leng y. Alzheimers Dement. 2023 Jan;19(1):158-168. doi: 10.1002/alz.12636. Epub 2022 Mar 17. Alzheimers Dement. 2023. PMID: 35297533 Free PMC article.
METHODS: Using data from 1401 participants of the Rush Memory and Aging Project, we examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer's dementia during up to 14-year follow-up. RESULTS: Older …
METHODS: Using data from 1401 participants of the Rush Memory and Aging Project, we examined the longitudinal change of daytime napping infe …
Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases.
Tao Y, Leng SX, Zhang H. Tao Y, et al. Among authors: leng sx. Curr Neuropharmacol. 2022 Nov 15;20(12):2303-2319. doi: 10.2174/1570159X20666220830102628. Curr Neuropharmacol. 2022. PMID: 36043794 Free PMC article. Review.
It also highlights the clinical evidence for the effects of the ketogenic diet in the treatment of Alzheimer's disease, Parkinson's disease, and motor neuron disease. Finally, it discusses the common adverse effects of ketogenic therapy. ...
It also highlights the clinical evidence for the effects of the ketogenic diet in the treatment of Alzheimer's disease, Parkinson' …
Mechanistic insight into sevoflurane-associated developmental neurotoxicity.
Sun M, Xie Z, Zhang J, Leng Y. Sun M, et al. Among authors: leng y. Cell Biol Toxicol. 2022 Dec;38(6):927-943. doi: 10.1007/s10565-021-09677-y. Epub 2021 Nov 12. Cell Biol Toxicol. 2022. PMID: 34766256 Free PMC article. Review.
More advanced technologies and methods should be applied to determine the underlying mechanism(s) and guide prevention and treatment of sevoflurane-induced neurotoxicity. 1. We discuss the mechanisms underlying sevoflurane-induced developmental neurotoxicity from five pers …
More advanced technologies and methods should be applied to determine the underlying mechanism(s) and guide prevention and treatment …
TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes.
Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. Dezfulian MH, et al. Among authors: leng y. Cell. 2023 Dec 7;186(25):5569-5586.e21. doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27. Cell. 2023. PMID: 38016469 Free article.
Leveraging genome-scale human, virome, and epitope mutagenesis libraries, TScan-II facilitates de novo antigen discovery and deep exploration of TCR specificity. We demonstrate TScan-II's potential for basic and translational research by identifying a non-canonical antigen …
Leveraging genome-scale human, virome, and epitope mutagenesis libraries, TScan-II facilitates de novo antigen discovery and deep exploratio …
CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.
Xie W, Guo D, Li J, Yue L, Kang Q, Chen G, Zhou T, Wang H, Zhuang K, Leng L, Li H, Chen Z, Gao W, Zhang J. Xie W, et al. Among authors: leng l. Cell Death Differ. 2022 Dec;29(12):2417-2428. doi: 10.1038/s41418-022-01027-7. Epub 2022 Jun 22. Cell Death Differ. 2022. PMID: 35732922 Free PMC article.
Alzheimer's disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impairments. ...Our study provides new mechanistic insights in mitochondrial function regulations by CEND1 in Alzheimer's disease....
Alzheimer's disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impair …
Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery.
Leng L, Xu Z, Hong B, Zhao B, Tian Y, Wang C, Yang L, Zou Z, Li L, Liu K, Peng W, Liu J, An Z, Wang Y, Duan B, Hu Z, Zheng C, Zhang S, Li X, Li M, Liu Z, Bi Z, He T, Liu B, Fan H, Song C, Tong Y, Chen S. Leng L, et al. Nat Commun. 2024 Feb 20;15(1):1537. doi: 10.1038/s41467-024-45690-5. Nat Commun. 2024. PMID: 38378731 Free PMC article.
Here, we assemble three Stephania genomes (S. japonica, S. yunnanensis, and S. cepharantha), propose the cepharanthine biosynthetic pathway, and assess the antiviral potential of compounds involved in the pathway. Among the three genomes, S. japonica h …
Here, we assemble three Stephania genomes (S. japonica, S. yunnanensis, and S. cepharantha), propose the cepharanthine …
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.
Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Kim H, et al. Among authors: leng k. Nat Commun. 2022 Nov 2;13(1):6581. doi: 10.1038/s41467-022-34412-4. Nat Commun. 2022. PMID: 36323693 Free PMC article.
6,155 results