Escherichia coli Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data.
Phaneuf PV, Zielinski DC, Yurkovich JT, Johnsen J, Szubin R, Yang L, Kim SH, Schulz S, Wu M, Dalldorf C, Ozdemir E, Lennen RM, Palsson BO, Feist AM.
Phaneuf PV, et al.
ACS Synth Biol. 2021 Dec 17;10(12):3379-3395. doi: 10.1021/acssynbio.1c00337. Epub 2021 Nov 11.
ACS Synth Biol. 2021.
PMID: 34762392
Free PMC article.
However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evolution (ALE) leverages nature's problem-solving processes to generate optimized genotypes currently inaccessible to rational methods. …
However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evo …