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Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.

Anand AA, Walter P. Anand AA, et al. FEBS J. 2020 Jan;287(2):239-245. doi: 10.1111/febs.15073. Epub 2019 Nov 7. FEBS J. 2020. PMID: 31550413 Free article. Review.

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Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.

Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. Yu Y, et al. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2026844118. doi: 10.1073/pnas.2026844118. Proc Natl Acad Sci U S A. 2021. PMID: 33941673 Free PMC article.

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Integrative structure and functional anatomy of a nuclear pore complex.

Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP. Kim SJ, et al. Nature. 2018 Mar 22;555(7697):475-482. doi: 10.1038/nature26003. Epub 2018 Mar 14. Nature. 2018. PMID: 29539637 Free PMC article.

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Structural basis of mitochondrial receptor binding and constriction by DRP1.

Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. Kalia R, et al. Nature. 2018 Jun;558(7710):401-405. doi: 10.1038/s41586-018-0211-2. Epub 2018 Jun 13. Nature. 2018. PMID: 29899447 Free PMC article.

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Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.

Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM. Yoshizawa T, et al. Cell. 2018 Apr 19;173(3):693-705.e22. doi: 10.1016/j.cell.2018.03.003. Cell. 2018. PMID: 29677513 Free PMC article.

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Structural basis of CD4 downregulation by HIV-1 Nef.

Kwon Y, Kaake RM, Echeverria I, Suarez M, Karimian Shamsabadi M, Stoneham C, Ramirez PW, Kress J, Singh R, Sali A, Krogan N, Guatelli J, Jia X. Kwon Y, et al. Nat Struct Mol Biol. 2020 Sep;27(9):822-828. doi: 10.1038/s41594-020-0463-z. Epub 2020 Jul 27. Nat Struct Mol Biol. 2020. PMID: 32719457 Free PMC article.

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Membrane constriction and thinning by sequential ESCRT-III polymerization.

Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR 3rd, Iwasa JH, Vershinin MD, Sundquist WI, Frost A. Nguyen HC, et al. Nat Struct Mol Biol. 2020 Apr;27(4):392-399. doi: 10.1038/s41594-020-0404-x. Epub 2020 Apr 6. Nat Struct Mol Biol. 2020. PMID: 32251413 Free PMC article.

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Integrative structure and function of the yeast exocyst complex.

Ganesan SJ, Feyder MJ, Chemmama IE, Fang F, Rout MP, Chait BT, Shi Y, Munson M, Sali A. Ganesan SJ, et al. Protein Sci. 2020 Jun;29(6):1486-1501. doi: 10.1002/pro.3863. Epub 2020 May 1. Protein Sci. 2020. PMID: 32239688 Free PMC article.

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The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex.

Hepburn M, Saltzberg DJ, Lee L, Fang S, Atkinson C, Strynadka NCJ, Sali A, Lees-Miller SP, Schriemer DC. Hepburn M, et al. Structure. 2021 May 6;29(5):467-478.e6. doi: 10.1016/j.str.2020.12.006. Epub 2021 Jan 6. Structure. 2021. PMID: 33412091 Free PMC article.

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CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation.

Brilot AF, Lyon AS, Zelter A, Viswanath S, Maxwell A, MacCoss MJ, Muller EG, Sali A, Davis TN, Agard DA. Brilot AF, et al. Elife. 2021 May 5;10:e65168. doi: 10.7554/eLife.65168. Elife. 2021. PMID: 33949948 Free PMC article.

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