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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 2
2005 2
2006 2
2007 6
2008 14
2009 4
2010 5
2011 1
2012 4
2013 7
2014 2
2017 2
2018 3
2019 5
2020 5
2021 6
2022 8
2023 10
2024 6

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85 results

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Page 1
Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma.
Mo Z, Liu D, Chen Y, Luo J, Li W, Liu J, Yu L, Huang B, Zhang S. Mo Z, et al. J Transl Med. 2022 Oct 11;20(1):466. doi: 10.1186/s12967-022-03675-2. J Transl Med. 2022. PMID: 36221095 Free PMC article.
Based on the MNT score, five relevant drugs (inhibitor of polo-like kinase 1, inhibitor of kinesin family member 11, dabrafenib, ispinesib, and epothilone-b) were predicted. CONCLUSIONS: This study reveals the crucial role of macrophage-naive CD4 + T cell interaction in th …
Based on the MNT score, five relevant drugs (inhibitor of polo-like kinase 1, inhibitor of kinesin family member 11, dabrafenib, ispinesi …
Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck.
Tang PA, Siu LL, Chen EX, Hotte SJ, Chia S, Schwarz JK, Pond GR, Johnson C, Colevas AD, Synold TW, Vasist LS, Winquist E. Tang PA, et al. Invest New Drugs. 2008 Jun;26(3):257-64. doi: 10.1007/s10637-007-9098-8. Epub 2007 Nov 24. Invest New Drugs. 2008. PMID: 18038218 Clinical Trial.
Ispinesib (SB-715992) inhibits the mitotic kinesin spindle protein (KSP), a novel target for anticancer therapy. A phase II study was conducted to examine the efficacy of ispinesib in recurrent or metastatic head and neck squamous cell carcinoma (RMHNSC). ...
Ispinesib (SB-715992) inhibits the mitotic kinesin spindle protein (KSP), a novel target for anticancer therapy. A phase II study was …
Inhibitor library screening identifies ispinesib as a new potential chemotherapeutic agent for pancreatic cancers.
Murase Y, Ono H, Ogawa K, Yoshioka R, Ishikawa Y, Ueda H, Akahoshi K, Ban D, Kudo A, Tanaka S, Tanabe M. Murase Y, et al. Cancer Sci. 2021 Nov;112(11):4641-4654. doi: 10.1111/cas.15134. Epub 2021 Oct 2. Cancer Sci. 2021. PMID: 34510663 Free PMC article.
Mechanistically, ispinesib acted by inducing incomplete mitosis with nuclear disruption, resulting in multinucleated monoastral spindle cells. ...Ispinesib, identified by inhibitor library screening, could be a promising novel therapeutic agent for pancreatic cancer …
Mechanistically, ispinesib acted by inducing incomplete mitosis with nuclear disruption, resulting in multinucleated monoastral spind …
Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma.
Cheng YL, Banu MA, Zhao W, Rosenfeld SS, Canoll P, Sims PA. Cheng YL, et al. bioRxiv [Preprint]. 2023 Sep 12:2023.09.09.557001. doi: 10.1101/2023.09.09.557001. bioRxiv. 2023. PMID: 37745469 Free PMC article. Preprint.
In contrast, cells subjected to long-term ispinesib treatment exhibited a proneural phenotype. We generated patient-derived xenografts to show that ispinesib-resistant cells form less aggressive tumors in vivo, even in the absence of drug. Finally, we used lineage b …
In contrast, cells subjected to long-term ispinesib treatment exhibited a proneural phenotype. We generated patient-derived xenograft …
Efficacy and Synergy of Small Molecule Inhibitors Targeting FLT3-ITD+ Acute Myeloid Leukemia.
Bregante J, Schönbichler A, Pölöske D, Degenfeld-Schonburg L, Monzó Contreras G, Hadzijusufovic E, de Araujo ED, Valent P, Moriggl R, Orlova A. Bregante J, et al. Cancers (Basel). 2021 Dec 8;13(24):6181. doi: 10.3390/cancers13246181. Cancers (Basel). 2021. PMID: 34944800 Free PMC article.
Among these, we characterized two investigational compounds, WS6 and ispinesib, and two approved drugs, ponatinib and cabozantinib, in depth. ...Together, we suggest WS6, ispinesib, ponatinib and cabozantinib as novel options for targeting FLT3-ITD(+) AML. ...
Among these, we characterized two investigational compounds, WS6 and ispinesib, and two approved drugs, ponatinib and cabozantinib, i …
A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.
Lee CW, Bélanger K, Rao SC, Petrella TM, Tozer RG, Wood L, Savage KJ, Eisenhauer EA, Synold TW, Wainman N, Seymour L. Lee CW, et al. Invest New Drugs. 2008 Jun;26(3):249-55. doi: 10.1007/s10637-007-9097-9. Epub 2007 Oct 26. Invest New Drugs. 2008. PMID: 17962907 Clinical Trial.
To assess the response rate and toxicity of the kinesin spindle protein (KSP) inhibitor, ispinesib, in malignant melanoma. Seventeen patients were enrolled from April to November 2005. Ispinesib was administered as a 1-hour infusion at a dose of 18 mg/m2 once every …
To assess the response rate and toxicity of the kinesin spindle protein (KSP) inhibitor, ispinesib, in malignant melanoma. Seventeen …
KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.
Jungwirth G, Yu T, Cao J, Eddine MA, Moustafa M, Warta R, Debus J, Unterberg A, Abdollahi A, Herold-Mende C. Jungwirth G, et al. Cancer Lett. 2021 May 28;506:1-10. doi: 10.1016/j.canlet.2021.02.016. Epub 2021 Feb 27. Cancer Lett. 2021. PMID: 33652084
Due to anti-tumor activity for KIF11 inhibitors (KIF11i) filanesib and ispinesib in other cancer types, we sought to investigate their mode of action and efficacy for the treatment of aggressive meningiomas. ...We identified substantial in vitro and in vivo anti-tumor effe …
Due to anti-tumor activity for KIF11 inhibitors (KIF11i) filanesib and ispinesib in other cancer types, we sought to investigate thei …
Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).
Dong G, Wu Y, Cheng J, Chen L, Liu R, Ding Y, Wu S, Ma J, Sheng C. Dong G, et al. J Med Chem. 2022 Jun 9;65(11):7619-7628. doi: 10.1021/acs.jmedchem.1c02001. Epub 2022 May 19. J Med Chem. 2022. PMID: 35588495
However, effective tools and successful examples for autophagosome-tethering chimeras are still rather limited. Herein, ATTEC ispinesib was identified for the first time to be an effective warhead to design autophagosome-tethering chimeras. ...Ispinesib may have bro …
However, effective tools and successful examples for autophagosome-tethering chimeras are still rather limited. Herein, ATTEC ispinesib …
Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer.
Purcell JW, Davis J, Reddy M, Martin S, Samayoa K, Vo H, Thomsen K, Bean P, Kuo WL, Ziyad S, Billig J, Feiler HS, Gray JW, Wood KW, Cases S. Purcell JW, et al. Clin Cancer Res. 2010 Jan 15;16(2):566-76. doi: 10.1158/1078-0432.CCR-09-1498. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068098 Free PMC article.
To better understand the potential of ispinesib in the treatment of breast cancer, we explored the activity of ispinesib alone and in combination with several therapies approved for the treatment of breast cancer. ...RESULTS: In vitro, ispinesib displayed bro …
To better understand the potential of ispinesib in the treatment of breast cancer, we explored the activity of ispinesib alone …
"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.
Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS. Kaan HY, et al. J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658017 Free PMC article.
In this study, we have used x-ray crystallography to identify a new structure of an Eg5-ispinesib complex and have combined this with transient state kinetics to identify a plausible sequence of conformational changes that occur in response to ispinesib binding. Our …
In this study, we have used x-ray crystallography to identify a new structure of an Eg5-ispinesib complex and have combined this with …
85 results