Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase.
Chen M, Guo Z, Sun J, Tang W, Wang M, Tang Y, Li P, Wu B, Chen Y.
Chen M, et al.
Acta Pharm Sin B. 2023 Feb;13(2):765-774. doi: 10.1016/j.apsb.2022.05.031. Epub 2022 Jun 3.
Acta Pharm Sin B. 2023.
PMID: 36873169
Free PMC article.
In this study, we deciphered the biosynthetic pathway of the l,l-gluco-heptosamine moiety in SEPs by functional characterizing four genes and proposed that SepI initiates the process by oxidizing the 4'-hydroxyl of l-glycero-alpha-d-manno-heptose moiety of SEP-328 (2) to a …
In this study, we deciphered the biosynthetic pathway of the l,l-gluco-heptosamine moiety in SEPs by functional characterizing four genes …