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Year Number of Results
1997 1
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1999 1
2001 1
2002 1
2003 9
2004 11
2005 17
2006 19
2007 18
2008 27
2009 21
2010 31
2011 29
2012 24
2013 29
2014 40
2015 37
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540 results

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Page 1
Sfrp4 and the Biology of Cortical Bone.
Chen R, Baron R, Gori F. Chen R, et al. Curr Osteoporos Rep. 2022 Apr;20(2):153-161. doi: 10.1007/s11914-022-00727-w. Epub 2022 Feb 19. Curr Osteoporos Rep. 2022. PMID: 35182301 Free PMC article. Review.
On the endosteal surface, Sfrp4-mediated repression of non-canonical Wnt signaling regulates endosteal resorption. On the periosteum, Sfrp4 identifies as a critical functional mediator of periosteal stem cell/progenitor expansion and differentiation. ...
On the endosteal surface, Sfrp4-mediated repression of non-canonical Wnt signaling regulates endosteal resorption. On the periosteum, …
Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.
Chen R, Dong H, Raval D, Maridas D, Baroi S, Chen K, Hu D, Berry SR, Baron R, Greenblatt MB, Gori F. Chen R, et al. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2312677120. doi: 10.1073/pnas.2312677120. Epub 2023 Nov 6. Proc Natl Acad Sci U S A. 2023. PMID: 37931101 Free PMC article.
Supporting these findings, Sfrp4 deletion hampers the periosteal response to bone injury and impairs Ctsk-lineage periosteal cell recruitment. Ctsk-lineage PSCs express the PTH receptor and PTH treatment increases the % of PSCs, a response not seen in the absence of Sfr
Supporting these findings, Sfrp4 deletion hampers the periosteal response to bone injury and impairs Ctsk-lineage periosteal cell rec …
Sfrp4 expression in thyroxine treated calvarial cells.
Durham EL, Grey ZJ, Black L, Howie RN, Barth JL, Lee BS, Cray JJ. Durham EL, et al. Life Sci. 2022 Dec 15;311(Pt A):121158. doi: 10.1016/j.lfs.2022.121158. Epub 2022 Nov 9. Life Sci. 2022. PMID: 36370870 Free PMC article.
Interrogation of the SFRP4 promoter identified multiple putative binding sites for thyroid hormone receptors. Experimentation with several cell lines demonstrated that thyroxine treatment induced Sfrp4 expression, demonstrating that Sfrp4 mRNA and protein lev …
Interrogation of the SFRP4 promoter identified multiple putative binding sites for thyroid hormone receptors. Experimentation with se …
SFRP4(+) stromal cell subpopulation with IGF1 signaling in human endometrial regeneration.
Wu B, Li Y, Nie N, Shen X, Jiang W, Liu Y, Gong L, An C, Zhao K, Yao X, Yuan C, Hu J, Zhao W, Qian J, Zou X. Wu B, et al. Cell Discov. 2022 Sep 27;8(1):95. doi: 10.1038/s41421-022-00438-7. Cell Discov. 2022. PMID: 36163341 Free PMC article.
We dissected cell heterogeneity of main cell types (epithelial, stromal, endothelial, and immune cells) of the full thickness uterine tissues, cell population architectures of human uterus cells across the menstrual cycle. We identified an SFRP4(+) stromal cell subpopulati …
We dissected cell heterogeneity of main cell types (epithelial, stromal, endothelial, and immune cells) of the full thickness uterine tissue …
SFRP4 Is a Potential Biomarker for the Prognosis and Immunotherapy for Gastric Cancer.
Yu P, He W, Zhang Y, Hu C, Wu Y, Wang Y, Bao Z, Xia Y, Zhang R, Cao M, Yuan L, Cheng X, Xu Z. Yu P, et al. J Oncol. 2022 Jul 5;2022:8829649. doi: 10.1155/2022/8829649. eCollection 2022. J Oncol. 2022. PMID: 35847366 Free PMC article.
The 5-year survival rate for patients with high SFRP4 expression was only 39.81% but reached 60.02% for patients with low SFRP4 expression. ...SFRP4 may be important for guiding immunotherapy in gastric cancer patients....
The 5-year survival rate for patients with high SFRP4 expression was only 39.81% but reached 60.02% for patients with low SFRP4
SFRP4 Reduces Atherosclerosis Plaque Formation in ApoE Deficient Mice.
Guan H, Liu T, Liu M, Wang X, Shi T, Guo F. Guan H, et al. Cardiol Res Pract. 2023 Apr 25;2023:8302289. doi: 10.1155/2023/8302289. eCollection 2023. Cardiol Res Pract. 2023. PMID: 37143778 Free PMC article.
However, there is not enough evidence to prove the antiatherosclerosis effect of SFRP4 in ApoE knock-out (KO) mice. ApoE KO mice were fed a western diet and injected adenovirus (Ad)-SFRP4 through the tail vein for 12 weeks. Contrasted with the control cohort, the ar …
However, there is not enough evidence to prove the antiatherosclerosis effect of SFRP4 in ApoE knock-out (KO) mice. ApoE KO mice were …
SFRP4 Is a Negative Regulator of Ovarian Follicle Development and Female Fertility.
Zamberlam G, Lapointe E, Abedini A, Rico C, Godin P, Paquet M, DeMayo FJ, Boerboom D. Zamberlam G, et al. Endocrinology. 2019 Jul 1;160(7):1561-1572. doi: 10.1210/en.2019-00212. Endocrinology. 2019. PMID: 30942852 Free PMC article.
In this study, we aimed to define the physiological roles of Sfrp4 in the ovary by gene targeting. Sfrp4-null female mice were found to produce larger litters than did their wild-type littermates. ...Increased expression of FSH- and LH-responsive genes was found in …
In this study, we aimed to define the physiological roles of Sfrp4 in the ovary by gene targeting. Sfrp4-null female mice were …
SFRP4(+)IGFBP5(hi) NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain.
Chen Y, Zhu J, Chen L, Shen Y, Zhang J, Wang Q. Chen Y, et al. Front Immunol. 2022 Nov 30;13:945504. doi: 10.3389/fimmu.2022.945504. eCollection 2022. Front Immunol. 2022. PMID: 36532077 Free PMC article.
RESULT: We found a specific population of secreted frizzled-related protein 4 (SFRP4)(+)NKT cells and a large amount of undifferentiated multipotent stem cells in the adenomyosis pain group. We discovered that a high expression of IGFBP5 in SFRP4(+)NKT cells could p …
RESULT: We found a specific population of secreted frizzled-related protein 4 (SFRP4)(+)NKT cells and a large amount of undifferentia …
Secreted frizzled related protein 4 (sFRP4) update: A brief review.
Pawar NM, Rao P. Pawar NM, et al. Cell Signal. 2018 May;45:63-70. doi: 10.1016/j.cellsig.2018.01.019. Epub 2018 Jan 31. Cell Signal. 2018. PMID: 29360572 Review.
In parallel, aberrant gene expression and abnormal secreted protein levels accompany a wide range of pathologies in humans. In this review, we provide a brief introduction to sFRP4, an update of the pathways it's involved, its various physiological actions that are reporte …
In parallel, aberrant gene expression and abnormal secreted protein levels accompany a wide range of pathologies in humans. In this review, …
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
Hörbelt T, Knebel B, Fahlbusch P, Barbosa D, de Wiza DH, Van de Velde F, Van Nieuwenhove Y, Lapauw B, Thoresen GH, Al-Hasani H, Müller-Wieland D, Ouwens DM, Kotzka J. Hörbelt T, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2671-2684. doi: 10.1016/j.bbadis.2019.07.008. Epub 2019 Jul 20. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31336149 Free article.
In hSkMC, sFRP4 induced glycolysis rather than inhibiting insulin signalling. Finally, in hepatocytes from aP2-SREBP-1c mice, sFRP4 potentiates existing insulin resistance. Collectively, we show that sFRP4 interferes with hepatocyte insulin action. ...
In hSkMC, sFRP4 induced glycolysis rather than inhibiting insulin signalling. Finally, in hepatocytes from aP2-SREBP-1c mice, sFRP
540 results