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Sodium-glucose co-transporter (SGLT)2 and SGLT1 renal expression in patients with type 2 diabetes.
Solini A, Rossi C, Mazzanti CM, Proietti A, Koepsell H, Ferrannini E. Solini A, et al. Diabetes Obes Metab. 2017 Sep;19(9):1289-1294. doi: 10.1111/dom.12970. Epub 2017 May 22. Diabetes Obes Metab. 2017. PMID: 28419670
METHODS: We measured SGLT2 and SGLT1 expression in unaffected renal tissue from 19 people with T2DM and 20 people without diabetes, matched for age and estimated glomerular filtration rate (controls), undergoing unilateral nephrectomy. ...CONCLU …
METHODS: We measured SGLT2 and SGLT1 expression in unaffected renal tissue from 19 people with T2DM and 2 …
Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model.
Shepard BD, Koepsell H, Pluznick JL. Shepard BD, et al. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F372-F381. doi: 10.1152/ajprenal.00069.2018. Epub 2018 Nov 28. Am J Physiol Renal Physiol. 2019. PMID: 30484350 Free PMC article.
Inhibition of Sglt2 is accepted as a viable therapeutic treatment option for patients with type 2 diabetes and has been shown to delay development of diabetic kidney disease. ...In addition, male and female WT mice developed diabetes-induced hyp …
Inhibition of Sglt2 is accepted as a viable therapeutic treatment option for patients with type 2 diabetes
Experimental type II diabetes and related models of impaired glucose metabolism differentially regulate glucose transporters at the proximal tubule brush border membrane.
Chichger H, Cleasby ME, Srai SK, Unwin RJ, Debnam ES, Marks J. Chichger H, et al. Exp Physiol. 2016 Jun 1;101(6):731-42. doi: 10.1113/EP085670. Epub 2016 May 10. Exp Physiol. 2016. PMID: 27164183 Free article.
In vivo models of metabolic disruption (Goto-Kakizaki type II diabetic rat and junk-food diet) demonstrate increased expression of SGLT1, SGLT2 and GLUT2 in the proximal tubule brush border. ...Junk-food and high-fat diet feeding also caused higher membrane …
In vivo models of metabolic disruption (Goto-Kakizaki type II diabetic rat and junk-food diet) demonstrate increased expression of …